Search Results

Overview

Uniprot ID	O94903
Protein Name	Pyridoxal phosphate homeostasis protein
Gene Name	PLPBP
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
254	FGERDYSKKPTPDKC
260	SKKPTPDKCAADVKA
266	DKCAADVKAPLEVAQ
99	HFIGHLQKQNVNKLM

Function

Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6

Protein Sequence

10 MWRAGSMSAE 20 LGVGCALRAV 30 NERVQQAVAR 40 RPRDLPAIQP 50 RLVAVSKTKP 60 ADMVIEAYGH 70 GQRTFGENYV 80 QELLEKASNP 90 KILSLCPEIK 100 WHFIGHLQKQ 110 NVNKLMAVPN 120 LFMLETVDSV 130 KLADKVNSSW 140 QRKGSPERLK 150 VMVQINTSGE 160 ESKHGLPPSE 170 TIAIVEHINA 180 KCPNLEFVGL 190 MTIGSFGHDL 200 SQGPNPDFQL 210 LLSLREELCK 220 KLNIPADQVE 230 LSMGMSADFQ 240 HAVEVGSTNV 250 RIGSTIFGER 260 DYSKKPTPDK 270 CAADVKAPLE VAQEH

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0030170	pyridoxal phosphate binding
Biological Process	GO:0042816	vitamin B6 metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.