Search Results

Overview

Uniprot IDO94905
Protein NameErlin-2
Gene NameERLIN2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
192 LMESEKTKLLIAAQK
199 KLLIAAQKQKVVEKE
205 QKQKVVEKEAETERK
236 YGQKVMEKETEKKIS
241 MEKETEKKISEIEDA
275 IAEANKLKLTPEYLQ
287 YLQLMKYKAIASNSK

Function

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:17502376, PubMed:19240031). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618)

Protein Sequence

10 MAQLGAVVAV 20 ASSFFCASLF 30 SAVHKIEEGH 40 IGVYYRGGAL 50 LTSTSGPGFH 60 LMLPFITSYK 70 SVQTTLQTDE 80 VKNVPCGTSG 90 GVMIYFDRIE 100 VVNFLVPNAV 110 YDIVKNYTAD 120 YDKALIFNKI 130 HHELNQFCSV 140 HTLQEVYIEL 150 FDQIDENLKL 160 ALQQDLTSMA 170 PGLVIQAVRV 180 TKPNIPEAIR 190 RNYELMESEK 200 TKLLIAAQKQ 210 KVVEKEAETE 220 RKKALIEAEK 230 VAQVAEITYG 240 QKVMEKETEK 250 KISEIEDAAF 260 LAREKAKADA 270 ECYTAMKIAE 280 ANKLKLTPEY 290 LQLMKYKAIA 300 SNSKIYFGKD 310 IPNMFMDSAG 320 SVSKQFEGLA 330 DKLSFGLEDE PLETATKEN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0015485 cholesterol binding
Molecular Function GO:0031625 ubiquitin protein ligase binding
Biological Process GO:0008203 cholesterol metabolic process
Biological Process GO:0036503 ERAD pathway
Biological Process GO:0045541 negative regulation of cholesterol biosynthetic process
Biological Process GO:0045717 negative regulation of fatty acid biosynthetic process
Biological Process GO:0045540 regulation of cholesterol biosynthetic process
Biological Process GO:0032933 SREBP signaling pathway

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.