Search Results

Overview

Uniprot IDO94913
Protein NamePre-mRNA cleavage complex 2 protein Pcf11
Gene NamePCF11
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1278 ELFSKLLKTGILKLS
331 QSDTKTSKTIPSEKL
365 DQLDSKSKSKSKSPS
382 KNKLSHTKDLKNQES
592 VENWQSSKSAKRWKS
595 WQSSKSAKRWKSGWE
598 SKSAKRWKSGWEENK
767 VARDGPTKMIFEGPN
775 MIFEGPNKLSPRIDG

Function

Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II

Protein Sequence

10 MSEQTPAEAG 20 AAGAREDACR 30 DYQSSLEDLT 40 FNSKPHINML 50 TILAEENLPF 60 AKEIVSLIEA 70 QTAKAPSSEK 80 LPVMYLMDSI 90 VKNVGREYLT 100 AFTKNLVATF 110 ICVFEKVDEN 120 TRKSLFKLRS 130 TWDEIFPLKK 140 LYALDVRVNS 150 LDPAWPIKPL 160 PPNVNTSSIH 170 VNPKFLNKSP 180 EEPSTPGTVV 190 SSPSISTPPI 200 VPDIQKNLTQ 210 EQLIRQQLLA 220 KQKQLLELQQ 230 KKLELELEQA 240 KAQLAVSLSV 250 QQETSNLGPG 260 SAPSKLHVSQ 270 IPPMAVKAPH 280 QVPVQSEKSR 290 PGPSLQIQDL 300 KGTNRDPRLN 310 RISQHSHGKD 320 QSHRKEFLMN 330 TLNQSDTKTS 340 KTIPSEKLNS 350 SKQEKSKSGE 360 KITKKELDQL 370 DSKSKSKSKS 380 PSPLKNKLSH 390 TKDLKNQESE 400 SMRLSDMNKR 410 DPRLKKHLQD 420 KTDGKDDDVK 430 EKRKTAEKKD 440 KDEHMKSSEH 450 RLAGSRNKII 460 NGIVQKQDTI 470 TEESEKQGTK 480 PGRSSTRKRS 490 RSRSPKSRSP 500 IIHSPKRRDR 510 RSPKRRQRSM 520 SPTSTPKAGK 530 IRQSGAKQSH 540 MEEFTPPSRE 550 DRNAKRSTKQ 560 DIRDPRRMKK 570 TEEERPQETT 580 NQHSTKSGTE 590 PKENVENWQS 600 SKSAKRWKSG 610 WEENKSLQQV 620 DEHSKPPHLR 630 HRESWSSTKG 640 ILSPRAPKQQ 650 QHRLSVDANL 660 QIPKELTLAS 670 KRELLQKTSE 680 RLASGEITQD 690 DFLVVVHQIR 700 QLFQYQEGVR 710 EEQRSPFNDR 720 FPLKRPRYED 730 SDKPFVDSPA 740 SRFAGLDTNQ 750 RLTALAEDRP 760 LFDGPSRPSV 770 ARDGPTKMIF 780 EGPNKLSPRI 790 DGPPTPASLR 800 FDGSPGQMGG 810 GGPLRFEGPQ 820 GQLGGGCPLR 830 FEGPPGPVGT 840 PLRFEGPIGQ 850 AGGGGFRFEG 860 SPGLRFEGSP 870 GGLRFEGPGG 880 QPVGGLRFEG 890 HRGQPVGGLR 900 FEGPHGQPVG 910 GLRFDNPRGQ 920 PVGGLRFEGG 930 HGPSGAAIRF 940 DGPHGQPGGG 950 IRFEGPLLQQ 960 GVGMRFEGPH 970 GQSVAGLRFE 980 GQHNQLGGNL 990 RFEGPHGQPG 1000 VGIRFEGPLV 1010 QQGGGMRFEG 1020 PSVPGGGLRI 1030 EGPLGQGGPR 1040 FEGCHALRFD 1050 GQPGQPSLLP 1060 RFDGLHGQPG 1070 PRFERTPGQP 1080 GPQRFDGPPG 1090 QQVQPRFDGV 1100 PQRFDGPQHQ 1110 QASRFDIPLG 1120 LQGTRFDNHP 1130 SQRLESVSFN 1140 QTGPYNDPPG 1150 NAFNAPSQGL 1160 QFQRHEQIFD 1170 SPQGPNFNGP 1180 HGPGNQSFSN 1190 PLNRASGHYF 1200 DEKNLQSSQF 1210 GNFGNIPAPM 1220 TVGNIQASQQ 1230 VLSGVAQPVA 1240 FGQGQQFLPV 1250 HPQNPGFVQN 1260 PSGALPKAYP 1270 DNHLSQVDVN 1280 ELFSKLLKTG 1290 ILKLSQTDSA 1300 TTQVSEVTAQ 1310 PPPEEEEDQN 1320 EDQDVPDLTN 1330 FTVEELKQRY 1340 DSVINRLYTG 1350 IQCYSCGMRF 1360 TTSQTDVYAD 1370 HLDWHYRQNR 1380 TEKDVSRKVT 1390 HRRWYYSLTD 1400 WIEFEEIADL 1410 EERAKSQFFE 1420 KVHEEVVLKT 1430 QEAAKEKEFQ 1440 SVPAGPAGAV 1450 ESCEICQEQF 1460 EQYWDEEEEE 1470 WHLKNAIRVD 1480 GKIYHPSCYE 1490 DYQNTSSFDC 1500 TPSPSKTPVE 1510 NPLNIMLNIV 1520 KNELQEPCDS 1530 PKVKEERIDT 1540 PPACTEESIA 1550 TPSEIKTEND TVESV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005849 mRNA cleavage factor complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0000993 RNA polymerase II complex binding
Biological Process GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway
Biological Process GO:0031440 regulation of mRNA 3'-end processing
Biological Process GO:0006369 termination of RNA polymerase II transcription

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.