Search Results

Overview

Uniprot ID	O94925
Protein Name	Glutaminase kidney isoform, mitochondrial
Gene Name	GLS
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
130	LVASGENKIKQGLLP
158	QEKIPVHKFITALKS
164	HKFITALKSTGLRTS
245	AKKQSGGKVADYIPQ
311	YVHRYVGKEPSGLRF
320	PSGLRFNKLFLNEDD
656	QGDSDNGKENQTVHK

Function

Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain (PubMed:30239721, PubMed:30575854, PubMed:30970188)

Protein Sequence

10 MMRLRGSGML 20 RDLLLRSPAG 30 VSATLRRAQP 40 LVTLCRRPRG 50 GGRPAAGPAA 60 AARLHPWWGG 70 GGWPAEPLAR 80 GLSSSPSEIL 90 QELGKGSTHP 100 QPGVSPPAAP 110 AAPGPKDGPG 120 ETDAFGNSEG 130 KELVASGENK 140 IKQGLLPSLE 150 DLLFYTIAEG 160 QEKIPVHKFI 170 TALKSTGLRT 180 SDPRLKECMD 190 MLRLTLQTTS 200 DGVMLDKDLF 210 KKCVQSNIVL 220 LTQAFRRKFV 230 IPDFMSFTSH 240 IDELYESAKK 250 QSGGKVADYI 260 PQLAKFSPDL 270 WGVSVCTVDG 280 QRHSTGDTKV 290 PFCLQSCVKP 300 LKYAIAVNDL 310 GTEYVHRYVG 320 KEPSGLRFNK 330 LFLNEDDKPH 340 NPMVNAGAIV 350 VTSLIKQGVN 360 NAEKFDYVMQ 370 FLNKMAGNEY 380 VGFSNATFQS 390 ERESGDRNFA 400 IGYYLKEKKC 410 FPEGTDMVGI 420 LDFYFQLCSI 430 EVTCESASVM 440 AATLANGGFC 450 PITGERVLSP 460 EAVRNTLSLM 470 HSCGMYDFSG 480 QFAFHVGLPA 490 KSGVAGGILL 500 VVPNVMGMMC 510 WSPPLDKMGN 520 SVKGIHFCHD 530 LVSLCNFHNY 540 DNLRHFAKKL 550 DPRREGGDQR 560 VKSVINLLFA 570 AYTGDVSALR 580 RFALSAMDME 590 QRDYDSRTAL 600 HVAAAEGHVE 610 VVKFLLEACK 620 VNPFPKDRWN 630 NTPMDEALHF 640 GHHDVFKILQ 650 EYQVQYTPQG 660 DSDNGKENQT VHKNLDGLL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0004359	glutaminase activity
Biological Process	GO:0006537	glutamate biosynthetic process
Biological Process	GO:0090461	intracellular glutamate homeostasis
Biological Process	GO:0006543	L-glutamine catabolic process
Biological Process	GO:0051289	protein homotetramerization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.