Search Results
Overview
| Uniprot ID | O94953 |
|---|---|
| Protein Name | Lysine-specific demethylase 4B |
| Gene Name | KDM4B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 602 | QAPSTFSKLKMEIKK |
Function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS)
Protein Sequence
10
MGSEDHGAQN
20
PSCKIMTFRP
30
TMEEFKDFNK
40
YVAYIESQGA
50
HRAGLAKIIP
60
PKEWKPRQTY
70
DDIDDVVIPA
80
PIQQVVTGQS
90
GLFTQYNIQK
100
KAMTVGEYRR
110
LANSEKYCTP
120
RHQDFDDLER
130
KYWKNLTFVS
140
PIYGADISGS
150
LYDDDVAQWN
160
IGSLRTILDM
170
VERECGTIIE
180
GVNTPYLYFG
190
MWKTTFAWHT
200
EDMDLYSINY
210
LHFGEPKSWY
220
AIPPEHGKRL
230
ERLAIGFFPG
240
SSQGCDAFLR
250
HKMTLISPII
260
LKKYGIPFSR
270
ITQEAGEFMI
280
TFPYGYHAGF
290
NHGFNCAEST
300
NFATLRWIDY
310
GKVATQCTCR
320
KDMVKISMDV
330
FVRILQPERY
340
ELWKQGKDLT
350
VLDHTRPTAL
360
TSPELSSWSA
370
SRASLKAKLL
380
RRSHRKRSQP
390
KKPKPEDPKF
400
PGEGTAGAAL
410
LEEAGGSVKE
420
EAGPEVDPEE
430
EEEEPQPLPH
440
GREAEGAEED
450
GRGKLRPTKA
460
KSERKKKSFG
470
LLPPQLPPPP
480
AHFPSEEALW
490
LPSPLEPPVL
500
GPGPAAMEES
510
PLPAPLNVVP
520
PEVPSEELEA
530
KPRPIIPMLY
540
VVPRPGKAAF
550
NQEHVSCQQA
560
FEHFAQKGPT
570
WKEPVSPMEL
580
TGPEDGAASS
590
GAGRMETKAR
600
AGEGQAPSTF
610
SKLKMEIKKS
620
RRHPLGRPPT
630
RSPLSVVKQE
640
ASSDEEASPF
650
SGEEDVSDPD
660
ALRPLLSLQW
670
KNRAASFQAE
680
RKFNAAAART
690
EPYCAICTLF
700
YPYCQALQTE
710
KEAPIASLGK
720
GCPATLPSKS
730
RQKTRPLIPE
740
MCFTSGGENT
750
EPLPANSYIG
760
DDGTSPLIAC
770
GKCCLQVHAS
780
CYGIRPELVN
790
EGWTCSRCAA
800
HAWTAECCLC
810
NLRGGALQMT
820
TDRRWIHVIC
830
AIAVPEARFL
840
NVIERHPVDI
850
SAIPEQRWKL
860
KCVYCRKRMK
870
KVSGACIQCS
880
YEHCSTSFHV
890
TCAHAAGVLM
900
EPDDWPYVVS
910
ITCLKHKSGG
920
HAVQLLRAVS
930
LGQVVITKNR
940
NGLYYRCRVI
950
GAASQTCYEV
960
NFDDGSYSDN
970
LYPESITSRD
980
CVQLGPPSEG
990
ELVELRWTDG
1000
NLYKAKFISS
1010
VTSHIYQVEF
1020
EDGSQLTVKR
1030
GDIFTLEEEL
1040
PKRVRSRLSL
1050
STGAPQEPAF
1060
SGEEAKAAKR
1070
PRVGTPLATE
1080
DSGRSQDYVA
1090
FVESLLQVQG
RPGAPF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0032452 | histone demethylase activity |
| Molecular Function | GO:0051864 | histone H3K36 demethylase activity |
| Molecular Function | GO:0032454 | histone H3K9 demethylase activity |
| Molecular Function | GO:0140684 | histone H3K9me2/H3K9me3 demethylase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0010468 | regulation of gene expression |
Reference
PMID: N/A