Search Results
Overview
| Uniprot ID | O94979 |
|---|---|
| Protein Name | Protein transport protein Sec31A |
| Gene Name | SEC31A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1109 | LPTKKITKKPIPDEH |
| 111 | SKIIAGDKEVVIAQN |
| 1110 | PTKKITKKPIPDEHL |
| 806 | SPKIPYEKQQLPKGR |
| 811 | YEKQQLPKGRPGPVA |
Function
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030127 | COPII vesicle coat |
| Cellular Component | GO:0030134 | COPII-coated ER to Golgi transport vesicle |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0070971 | endoplasmic reticulum exit site |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0012507 | ER to Golgi transport vesicle membrane |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0030120 | vesicle coat |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0005198 | structural molecule activity |
| Biological Process | GO:0090110 | COPII-coated vesicle cargo loading |
| Biological Process | GO:0007029 | endoplasmic reticulum organization |
| Biological Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process | GO:1902953 | positive regulation of ER to Golgi vesicle-mediated transport |
| Biological Process | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0051592 | response to calcium ion |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.