Overview
| Uniprot ID | O95140 |
|---|
| Protein Name | Mitofusin-2 |
|---|
| Gene Name | MFN2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 719 |
QEIAAMNKKIEVLDS |
Function
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:19889647, PubMed:26214738, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity)
Protein Sequence
10
MSLLFSRCNS
20
IVTVKKNKRH
30
MAEVNASPLK
40
HFVTAKKKIN
50
GIFEQLGAYI
60
QESATFLEDT
70
YRNAELDPVT
80
TEEQVLDVKG
90
YLSKVRGISE
100
VLARRHMKVA
110
FFGRTSNGKS
120
TVINAMLWDK
130
VLPSGIGHTT
140
NCFLRVEGTD
150
GHEAFLLTEG
160
SEEKRSAKTV
170
NQLAHALHQD
180
KQLHAGSLVS
190
VMWPNSKCPL
200
LKDDLVLMDS
210
PGIDVTTELD
220
SWIDKFCLDA
230
DVFVLVANSE
240
STLMQTEKHF
250
FHKVSERLSR
260
PNIFILNNRW
270
DASASEPEYM
280
EEVRRQHMER
290
CTSFLVDELG
300
VVDRSQAGDR
310
IFFVSAKEVL
320
NARIQKAQGM
330
PEGGGALAEG
340
FQVRMFEFQN
350
FERRFEECIS
360
QSAVKTKFEQ
370
HTVRAKQIAE
380
AVRLIMDSLH
390
MAAREQQVYC
400
EEMREERQDR
410
LKFIDKQLEL
420
LAQDYKLRIK
430
QITEEVERQV
440
STAMAEEIRR
450
LSVLVDDYQM
460
DFHPSPVVLK
470
VYKNELHRHI
480
EEGLGRNMSD
490
RCSTAITNSL
500
QTMQQDMIDG
510
LKPLLPVSVR
520
SQIDMLVPRQ
530
CFSLNYDLNC
540
DKLCADFQED
550
IEFHFSLGWT
560
MLVNRFLGPK
570
NSRRALMGYN
580
DQVQRPIPLT
590
PANPSMPPLP
600
QGSLTQEEFM
610
VSMVTGLASL
620
TSRTSMGILV
630
VGGVVWKAVG
640
WRLIALSFGL
650
YGLLYVYERL
660
TWTTKAKERA
670
FKRQFVEHAS
680
EKLQLVISYT
690
GSNCSHQVQQ
700
ELSGTFAHLC
710
QQVDVTRENL
720
EQEIAAMNKK
730
IEVLDSLQSK
740
AKLLRNKAGW
750
LDSELNMFTH
QYLQPSR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0015630 |
microtubule cytoskeleton |
| Cellular Component |
GO:0005741 |
mitochondrial outer membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Biological Process |
GO:0009060 |
aerobic respiration |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0008053 |
mitochondrial fusion |
| Biological Process |
GO:0007006 |
mitochondrial membrane organization |
| Biological Process |
GO:0051646 |
mitochondrion localization |
| Biological Process |
GO:0046580 |
negative regulation of Ras protein signal transduction |
| Biological Process |
GO:0048662 |
negative regulation of smooth muscle cell proliferation |
| Biological Process |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
| Biological Process |
GO:1905461 |
positive regulation of vascular associated smooth muscle cell apoptotic process |
| Biological Process |
GO:1904707 |
positive regulation of vascular associated smooth muscle cell proliferation |
| Biological Process |
GO:0034497 |
protein localization to phagophore assembly site |
| Biological Process |
GO:0006626 |
protein targeting to mitochondrion |
| Biological Process |
GO:0006986 |
response to unfolded protein |
| Biological Process |
GO:0061734 |
type 2 mitophagy |
Reference
PMID: N/A