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Overview

Uniprot IDO95154
Protein NameAldo-keto reductase family 7 member A3
Gene NameAKR7A3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
100 FQLETSLKRLQCPRV
208 AGGLLTGKYKYEDKN
238 MYRNRYWKEHHFEGI

Function

Catalyzes the NADPH-dependent reduction of various carbonyl-containing compounds, including aldehydes, ketones, and toxic products from cellular metabolism or environmental exposure. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates, thus preventing the formation of protein adducts that contribute to AFB1-induced toxicity

Protein Sequence

10 MSRQLSRARP 20 ATVLGAMEMG 30 RRMDAPTSAA 40 VTRAFLERGH 50 TEIDTAFVYS 60 EGQSETILGG 70 LGLRLGGSDC 80 RVKIDTKAIP 90 LFGNSLKPDS 100 LRFQLETSLK 110 RLQCPRVDLF 120 YLHMPDHSTP 130 VEETLRACHQ 140 LHQEGKFVEL 150 GLSNYAAWEV 160 AEICTLCKSN 170 GWILPTVYQG 180 MYNAITRQVE 190 TELFPCLRHF 200 GLRFYAFNPL 210 AGGLLTGKYK 220 YEDKNGKQPV 230 GRFFGNTWAE 240 MYRNRYWKEH 250 HFEGIALVEK 260 ALQAAYGASA 270 PSMTSATLRW 280 MYHHSQLQGA 290 HGDAVILGMS 300 SLEQLEQNLA 310 AAEEGPLEPA 320 VVDAFNQAWH 330 LVTHECPNYF R

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Molecular Function GO:0008106 alcohol dehydrogenase (NADP+) activity
Molecular Function GO:0009055 electron transfer activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0070401 NADP+ binding
Biological Process GO:0046223 aflatoxin catabolic process
Biological Process GO:0006081 aldehyde metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.