Search Results

Overview

Uniprot IDO95163
Protein NameElongator complex protein 1
Gene NameELP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1110 DIIETNVKPSILEAQ
1118 PSILEAQKNYMAFLD

Function

Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (PubMed:9751059)

Protein Sequence

10 MRNLKLFRTL 20 EFRDIQGPGN 30 PQCFSLRTEQ 40 GTVLIGSEHG 50 LIEVDPVSRE 60 VKNEVSLVAE 70 GFLPEDGSGR 80 IVGVQDLLDQ 90 ESVCVATASG 100 DVILCSLSTQ 110 QLECVGSVAS 120 GISVMSWSPD 130 QELVLLATGQ 140 QTLIMMTKDF 150 EPILEQQIHQ 160 DDFGESKFIT 170 VGWGRKETQF 180 HGSEGRQAAF 190 QMQMHESALP 200 WDDHRPQVTW 210 RGDGQFFAVS 220 VVCPETGARK 230 VRVWNREFAL 240 QSTSEPVAGL 250 GPALAWKPSG 260 SLIASTQDKP 270 NQQDIVFFEK 280 NGLLHGHFTL 290 PFLKDEVKVN 300 DLLWNADSSV 310 LAVWLEDLQR 320 EESSIPKTCV 330 QLWTVGNYHW 340 YLKQSLSFST 350 CGKSKIVSLM 360 WDPVTPYRLH 370 VLCQGWHYLA 380 YDWHWTTDRS 390 VGDNSSDLSN 400 VAVIDGNRVL 410 VTVFRQTVVP 420 PPMCTYQLLF 430 PHPVNQVTFL 440 AHPQKSNDLA 450 VLDASNQISV 460 YKCGDCPSAD 470 PTVKLGAVGG 480 SGFKVCLRTP 490 HLEKRYKIQF 500 ENNEDQDVNP 510 LKLGLLTWIE 520 EDVFLAVSHS 530 EFSPRSVIHH 540 LTAASSEMDE 550 EHGQLNVSSS 560 AAVDGVIISL 570 CCNSKTKSVV 580 LQLADGQIFK 590 YLWESPSLAI 600 KPWKNSGGFP 610 VRFPYPCTQT 620 ELAMIGEEEC 630 VLGLTDRCRF 640 FINDIEVASN 650 ITSFAVYDEF 660 LLLTTHSHTC 670 QCFCLRDASF 680 KTLQAGLSSN 690 HVSHGEVLRK 700 VERGSRIVTV 710 VPQDTKLVLQ 720 MPRGNLEVVH 730 HRALVLAQIR 740 KWLDKLMFKE 750 AFECMRKLRI 760 NLNLIYDHNP 770 KVFLGNVETF 780 IKQIDSVNHI 790 NLFFTELKEE 800 DVTKTMYPAP 810 VTSSVYLSRD 820 PDGNKIDLVC 830 DAMRAVMESI 840 NPHKYCLSIL 850 TSHVKKTTPE 860 LEIVLQKVHE 870 LQGNAPSDPD 880 AVSAEEALKY 890 LLHLVDVNEL 900 YDHSLGTYDF 910 DLVLMVAEKS 920 QKDPKEYLPF 930 LNTLKKMETN 940 YQRFTIDKYL 950 KRYEKAIGHL 960 SKCGPEYFPE 970 CLNLIKDKNL 980 YNEALKLYSP 990 SSQQYQDISI 1000 AYGEHLMQEH 1010 MYEPAGLMFA 1020 RCGAHEKALS 1030 AFLTCGNWKQ 1040 ALCVAAQLNF 1050 TKDQLVGLGR 1060 TLAGKLVEQR 1070 KHIDAAMVLE 1080 ECAQDYEEAV 1090 LLLLEGAAWE 1100 EALRLVYKYN 1110 RLDIIETNVK 1120 PSILEAQKNY 1130 MAFLDSQTAT 1140 FSRHKKRLLV 1150 VRELKEQAQQ 1160 AGLDDEVPHG 1170 QESDLFSETS 1180 SVVSGSEMSG 1190 KYSHSNSRIS 1200 ARSSKNRRKA 1210 ERKKHSLKEG 1220 SPLEDLALLE 1230 ALSEVVQNTE 1240 NLKDEVYHIL 1250 KVLFLFEFDE 1260 QGRELQKAFE 1270 DTLQLMERSL 1280 PEIWTLTYQQ 1290 NSATPVLGPN 1300 STANSIMASY 1310 QQQKTSVPVL 1320 DAELFIPPKI 1330 NRRTQWKLSL LD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0033588 elongator holoenzyme complex
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0000049 tRNA binding
Biological Process GO:0006417 regulation of translation
Biological Process GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
Biological Process GO:0002098 tRNA wobble uridine modification

Reference

PMID: N/A