Search Results
Overview
| Uniprot ID | O95171 |
|---|---|
| Protein Name | Sciellin |
| Gene Name | SCEL |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 633 | KPLGVETKMILDELQ |
| 649 | CCHSTCFKCEICKQP |
Function
May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope
Protein Sequence
10
MSNVTLRKMS
20
PTGNEMKSTT
30
QGTTRKQQDF
40
HEVNKRRTFL
50
QDNSWIKKRP
60
EEEKDENYGR
70
VVLNRHNSHD
80
ALDRKVNERD
90
VPKATISRYS
100
SDDTLDRISD
110
RNDAAKTYKA
120
NTLDNQLTNR
130
SMSMFRSLEV
140
TKLQPGGSLN
150
ANTSNTIAST
160
SATTPVKKKR
170
QSWFPPPPPG
180
YNASSSTGTR
190
RREPGVHPPI
200
PPKPSSPVSS
210
PNQLRQDNRQ
220
IHPPKPGVYT
230
ETNRSAERNI
240
RSQDLDNIVK
250
VATSLQRSDK
260
GEELDNLIKM
270
NKSLNRNQGL
280
DSLFRANPKV
290
EEREKRAKSL
300
ESLIYMSTRT
310
DKDGKGIQSL
320
GSPIKVNQRT
330
DKNEKGRQNL
340
ESVAKVNARM
350
NKTSRRSEDL
360
DNATEVNPKG
370
HENTTGKKDL
380
DGLIKVDPET
390
NKNITRGQSL
400
DNLIKVTPEV
410
KRSNQGSKDL
420
NNFIKVYPGT
430
EKSTEGGQSL
440
DSLIKVTPER
450
NRTNQGNQDL
460
ENLIKVIPSA
470
NKSSEQGLDE
480
HINVSPKAVK
490
NTDGKQDLDK
500
LIKVNPEIFT
510
NNQRNQDLAN
520
LIKVNPAVIR
530
NNQSQDLDNL
540
IKVKPSALRN
550
TNRDQNLENL
560
IEVNSHVSEN
570
KNGSSNTGAK
580
QAGPQDTVVY
590
TRTYVENSKS
600
PKDGYQENIS
610
GKYIQTVYST
620
SDRSVIERDM
630
CTYCRKPLGV
640
ETKMILDELQ
650
ICCHSTCFKC
660
EICKQPLENL
670
QAGDSIWIYR
680
QTIHCEPCYS
KIMAKWIP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001533 | cornified envelope |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0009792 | embryo development ending in birth or egg hatching |
| Biological Process | GO:0008544 | epidermis development |
| Biological Process | GO:0030216 | keratinocyte differentiation |
| Biological Process | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0009612 | response to mechanical stimulus |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.