Overview
| Uniprot ID | O95180 |
| Protein Name | Voltage-dependent T-type calcium channel subunit alpha-1H |
| Gene Name | CACNA1H |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 1089 |
ATPMPTPKSSPFLDA |
Function
Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216)
Protein Sequence
10
MTEGARAADE
20
VRVPLGAPPP
30
GPAALVGASP
40
ESPGAPGREA
50
ERGSELGVSP
60
SESPAAERGA
70
ELGADEEQRV
80
PYPALAATVF
90
FCLGQTTRPR
100
SWCLRLVCNP
110
WFEHVSMLVI
120
MLNCVTLGMF
130
RPCEDVECGS
140
ERCNILEAFD
150
AFIFAFFAVE
160
MVIKMVALGL
170
FGQKCYLGDT
180
WNRLDFFIVV
190
AGMMEYSLDG
200
HNVSLSAIRT
210
VRVLRPLRAI
220
NRVPSMRILV
230
TLLLDTLPML
240
GNVLLLCFFV
250
FFIFGIVGVQ
260
LWAGLLRNRC
270
FLDSAFVRNN
280
NLTFLRPYYQ
290
TEEGEENPFI
300
CSSRRDNGMQ
310
KCSHIPGRRE
320
LRMPCTLGWE
330
AYTQPQAEGV
340
GAARNACINW
350
NQYYNVCRSG
360
DSNPHNGAIN
370
FDNIGYAWIA
380
IFQVITLEGW
390
VDIMYYVMDA
400
HSFYNFIYFI
410
LLIIVGSFFM
420
INLCLVVIAT
430
QFSETKQRES
440
QLMREQRARH
450
LSNDSTLASF
460
SEPGSCYEEL
470
LKYVGHIFRK
480
VKRRSLRLYA
490
RWQSRWRKKV
500
DPSAVQGQGP
510
GHRQRRAGRH
520
TASVHHLVYH
530
HHHHHHHHYH
540
FSHGSPRRPG
550
PEPGACDTRL
560
VRAGAPPSPP
570
SPGRGPPDAE
580
SVHSIYHADC
590
HIEGPQERAR
600
VAHAAATAAA
610
SLRLATGLGT
620
MNYPTILPSG
630
VGSGKGSTSP
640
GPKGKWAGGP
650
PGTGGHGPLS
660
LNSPDPYEKI
670
PHVVGEHGLG
680
QAPGHLSGLS
690
VPCPLPSPPA
700
GTLTCELKSC
710
PYCTRALEDP
720
EGELSGSESG
730
DSDGRGVYEF
740
TQDVRHGDRW
750
DPTRPPRATD
760
TPGPGPGSPQ
770
RRAQQRAAPG
780
EPGWMGRLWV
790
TFSGKLRRIV
800
DSKYFSRGIM
810
MAILVNTLSM
820
GVEYHEQPEE
830
LTNALEISNI
840
VFTSMFALEM
850
LLKLLACGPL
860
GYIRNPYNIF
870
DGIIVVISVW
880
EIVGQADGGL
890
SVLRTFRLLR
900
VLKLVRFLPA
910
LRRQLVVLVK
920
TMDNVATFCT
930
LLMLFIFIFS
940
ILGMHLFGCK
950
FSLKTDTGDT
960
VPDRKNFDSL
970
LWAIVTVFQI
980
LTQEDWNVVL
990
YNGMASTSSW
1000
AALYFVALMT
1010
FGNYVLFNLL
1020
VAILVEGFQA
1030
EGDANRSDTD
1040
EDKTSVHFEE
1050
DFHKLRELQT
1060
TELKMCSLAV
1070
TPNGHLEGRG
1080
SLSPPLIMCT
1090
AATPMPTPKS
1100
SPFLDAAPSL
1110
PDSRRGSSSS
1120
GDPPLGDQKP
1130
PASLRSSPCA
1140
PWGPSGAWSS
1150
RRSSWSSLGR
1160
APSLKRRGQC
1170
GERESLLSGE
1180
GKGSTDDEAE
1190
DGRAAPGPRA
1200
TPLRRAESLD
1210
PRPLRPAALP
1220
PTKCRDRDGQ
1230
VVALPSDFFL
1240
RIDSHREDAA
1250
ELDDDSEDSC
1260
CLRLHKVLEP
1270
YKPQWCRSRE
1280
AWALYLFSPQ
1290
NRFRVSCQKV
1300
ITHKMFDHVV
1310
LVFIFLNCVT
1320
IALERPDIDP
1330
GSTERVFLSV
1340
SNYIFTAIFV
1350
AEMMVKVVAL
1360
GLLSGEHAYL
1370
QSSWNLLDGL
1380
LVLVSLVDIV
1390
VAMASAGGAK
1400
ILGVLRVLRL
1410
LRTLRPLRVI
1420
SRAPGLKLVV
1430
ETLISSLRPI
1440
GNIVLICCAF
1450
FIIFGILGVQ
1460
LFKGKFYYCE
1470
GPDTRNISTK
1480
AQCRAAHYRW
1490
VRRKYNFDNL
1500
GQALMSLFVL
1510
SSKDGWVNIM
1520
YDGLDAVGVD
1530
QQPVQNHNPW
1540
MLLYFISFLL
1550
IVSFFVLNMF
1560
VGVVVENFHK
1570
CRQHQEAEEA
1580
RRREEKRLRR
1590
LERRRRSTFP
1600
SPEAQRRPYY
1610
ADYSPTRRSI
1620
HSLCTSHYLD
1630
LFITFIICVN
1640
VITMSMEHYN
1650
QPKSLDEALK
1660
YCNYVFTIVF
1670
VFEAALKLVA
1680
FGFRRFFKDR
1690
WNQLDLAIVL
1700
LSLMGITLEE
1710
IEMSAALPIN
1720
PTIIRIMRVL
1730
RIARVLKLLK
1740
MATGMRALLD
1750
TVVQALPQVG
1760
NLGLLFMLLF
1770
FIYAALGVEL
1780
FGRLECSEDN
1790
PCEGLSRHAT
1800
FSNFGMAFLT
1810
LFRVSTGDNW
1820
NGIMKDTLRE
1830
CSREDKHCLS
1840
YLPALSPVYF
1850
VTFVLVAQFV
1860
LVNVVVAVLM
1870
KHLEESNKEA
1880
REDAELDAEI
1890
ELEMAQGPGS
1900
ARRVDADRPP
1910
LPQESPGARD
1920
APNLVARKVS
1930
VSRMLSLPND
1940
SYMFRPVVPA
1950
SAPHPRPLQE
1960
VEMETYGAGT
1970
PLGSVASVHS
1980
PPAESCASLQ
1990
IPLAVSSPAR
2000
SGEPLHALSP
2010
RGTARSPSLS
2020
RLLCRQEAVH
2030
TDSLEGKIDS
2040
PRDTLDPAEP
2050
GEKTPVRPVT
2060
QGGSLQSPPR
2070
SPRPASVRTR
2080
KHTFGQRCVS
2090
SRPAAPGGEE
2100
AEASDPADEE
2110
VSHITSSACP
2120
WQPTAEPHGP
2130
EASPVAGGER
2140
DLRRLYSVDA
2150
QGFLDKPGRA
2160
DEQWRPSAEL
2170
GSGEPGEAKA
2180
WGPEAEPALG
2190
ARRKKKMSPP
2200
CISVEPPAED
2210
EGSARPSAAE
2220
GGSTTLRRRT
2230
PSCEATPHRD
2240
SLEPTEGSGA
2250
GGDPAAKGER
2260
WGQASCRAEH
2270
LTVPSFAFEP
2280
LDLGVPSGDP
2290
FLDGSHSVTP
2300
ESRASSSGAI
2310
VPLEPPESEP
2320
PMPVGDPPEK
2330
RRGLYLTVPQ
2340
CPLEKPGSPS
2350
ATPAPGGGAD
DPV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0005891 |
voltage-gated calcium channel complex |
| Molecular Function |
GO:0008331 |
high voltage-gated calcium channel activity |
| Molecular Function |
GO:0008332 |
low voltage-gated calcium channel activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0097110 |
scaffold protein binding |
| Molecular Function |
GO:0005245 |
voltage-gated calcium channel activity |
| Molecular Function |
GO:0005244 |
voltage-gated monoatomic ion channel activity |
| Biological Process |
GO:0032342 |
aldosterone biosynthetic process |
| Biological Process |
GO:0070509 |
calcium ion import |
| Biological Process |
GO:0098703 |
calcium ion import across plasma membrane |
| Biological Process |
GO:0032870 |
cellular response to hormone stimulus |
| Biological Process |
GO:0035865 |
cellular response to potassium ion |
| Biological Process |
GO:0034651 |
cortisol biosynthetic process |
| Biological Process |
GO:0006936 |
muscle contraction |
| Biological Process |
GO:0007517 |
muscle organ development |
| Biological Process |
GO:0007520 |
myoblast fusion |
| Biological Process |
GO:2000344 |
positive regulation of acrosome reaction |
| Biological Process |
GO:0008016 |
regulation of heart contraction |
| Biological Process |
GO:0042391 |
regulation of membrane potential |
| Biological Process |
GO:0055085 |
transmembrane transport |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.