Search Results

Overview

Uniprot IDO95180
Protein NameVoltage-dependent T-type calcium channel subunit alpha-1H
Gene NameCACNA1H
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1089 ATPMPTPKSSPFLDA

Function

Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:27149520, PubMed:9670923, PubMed:9930755). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216)

Protein Sequence

10 MTEGARAADE 20 VRVPLGAPPP 30 GPAALVGASP 40 ESPGAPGREA 50 ERGSELGVSP 60 SESPAAERGA 70 ELGADEEQRV 80 PYPALAATVF 90 FCLGQTTRPR 100 SWCLRLVCNP 110 WFEHVSMLVI 120 MLNCVTLGMF 130 RPCEDVECGS 140 ERCNILEAFD 150 AFIFAFFAVE 160 MVIKMVALGL 170 FGQKCYLGDT 180 WNRLDFFIVV 190 AGMMEYSLDG 200 HNVSLSAIRT 210 VRVLRPLRAI 220 NRVPSMRILV 230 TLLLDTLPML 240 GNVLLLCFFV 250 FFIFGIVGVQ 260 LWAGLLRNRC 270 FLDSAFVRNN 280 NLTFLRPYYQ 290 TEEGEENPFI 300 CSSRRDNGMQ 310 KCSHIPGRRE 320 LRMPCTLGWE 330 AYTQPQAEGV 340 GAARNACINW 350 NQYYNVCRSG 360 DSNPHNGAIN 370 FDNIGYAWIA 380 IFQVITLEGW 390 VDIMYYVMDA 400 HSFYNFIYFI 410 LLIIVGSFFM 420 INLCLVVIAT 430 QFSETKQRES 440 QLMREQRARH 450 LSNDSTLASF 460 SEPGSCYEEL 470 LKYVGHIFRK 480 VKRRSLRLYA 490 RWQSRWRKKV 500 DPSAVQGQGP 510 GHRQRRAGRH 520 TASVHHLVYH 530 HHHHHHHHYH 540 FSHGSPRRPG 550 PEPGACDTRL 560 VRAGAPPSPP 570 SPGRGPPDAE 580 SVHSIYHADC 590 HIEGPQERAR 600 VAHAAATAAA 610 SLRLATGLGT 620 MNYPTILPSG 630 VGSGKGSTSP 640 GPKGKWAGGP 650 PGTGGHGPLS 660 LNSPDPYEKI 670 PHVVGEHGLG 680 QAPGHLSGLS 690 VPCPLPSPPA 700 GTLTCELKSC 710 PYCTRALEDP 720 EGELSGSESG 730 DSDGRGVYEF 740 TQDVRHGDRW 750 DPTRPPRATD 760 TPGPGPGSPQ 770 RRAQQRAAPG 780 EPGWMGRLWV 790 TFSGKLRRIV 800 DSKYFSRGIM 810 MAILVNTLSM 820 GVEYHEQPEE 830 LTNALEISNI 840 VFTSMFALEM 850 LLKLLACGPL 860 GYIRNPYNIF 870 DGIIVVISVW 880 EIVGQADGGL 890 SVLRTFRLLR 900 VLKLVRFLPA 910 LRRQLVVLVK 920 TMDNVATFCT 930 LLMLFIFIFS 940 ILGMHLFGCK 950 FSLKTDTGDT 960 VPDRKNFDSL 970 LWAIVTVFQI 980 LTQEDWNVVL 990 YNGMASTSSW 1000 AALYFVALMT 1010 FGNYVLFNLL 1020 VAILVEGFQA 1030 EGDANRSDTD 1040 EDKTSVHFEE 1050 DFHKLRELQT 1060 TELKMCSLAV 1070 TPNGHLEGRG 1080 SLSPPLIMCT 1090 AATPMPTPKS 1100 SPFLDAAPSL 1110 PDSRRGSSSS 1120 GDPPLGDQKP 1130 PASLRSSPCA 1140 PWGPSGAWSS 1150 RRSSWSSLGR 1160 APSLKRRGQC 1170 GERESLLSGE 1180 GKGSTDDEAE 1190 DGRAAPGPRA 1200 TPLRRAESLD 1210 PRPLRPAALP 1220 PTKCRDRDGQ 1230 VVALPSDFFL 1240 RIDSHREDAA 1250 ELDDDSEDSC 1260 CLRLHKVLEP 1270 YKPQWCRSRE 1280 AWALYLFSPQ 1290 NRFRVSCQKV 1300 ITHKMFDHVV 1310 LVFIFLNCVT 1320 IALERPDIDP 1330 GSTERVFLSV 1340 SNYIFTAIFV 1350 AEMMVKVVAL 1360 GLLSGEHAYL 1370 QSSWNLLDGL 1380 LVLVSLVDIV 1390 VAMASAGGAK 1400 ILGVLRVLRL 1410 LRTLRPLRVI 1420 SRAPGLKLVV 1430 ETLISSLRPI 1440 GNIVLICCAF 1450 FIIFGILGVQ 1460 LFKGKFYYCE 1470 GPDTRNISTK 1480 AQCRAAHYRW 1490 VRRKYNFDNL 1500 GQALMSLFVL 1510 SSKDGWVNIM 1520 YDGLDAVGVD 1530 QQPVQNHNPW 1540 MLLYFISFLL 1550 IVSFFVLNMF 1560 VGVVVENFHK 1570 CRQHQEAEEA 1580 RRREEKRLRR 1590 LERRRRSTFP 1600 SPEAQRRPYY 1610 ADYSPTRRSI 1620 HSLCTSHYLD 1630 LFITFIICVN 1640 VITMSMEHYN 1650 QPKSLDEALK 1660 YCNYVFTIVF 1670 VFEAALKLVA 1680 FGFRRFFKDR 1690 WNQLDLAIVL 1700 LSLMGITLEE 1710 IEMSAALPIN 1720 PTIIRIMRVL 1730 RIARVLKLLK 1740 MATGMRALLD 1750 TVVQALPQVG 1760 NLGLLFMLLF 1770 FIYAALGVEL 1780 FGRLECSEDN 1790 PCEGLSRHAT 1800 FSNFGMAFLT 1810 LFRVSTGDNW 1820 NGIMKDTLRE 1830 CSREDKHCLS 1840 YLPALSPVYF 1850 VTFVLVAQFV 1860 LVNVVVAVLM 1870 KHLEESNKEA 1880 REDAELDAEI 1890 ELEMAQGPGS 1900 ARRVDADRPP 1910 LPQESPGARD 1920 APNLVARKVS 1930 VSRMLSLPND 1940 SYMFRPVVPA 1950 SAPHPRPLQE 1960 VEMETYGAGT 1970 PLGSVASVHS 1980 PPAESCASLQ 1990 IPLAVSSPAR 2000 SGEPLHALSP 2010 RGTARSPSLS 2020 RLLCRQEAVH 2030 TDSLEGKIDS 2040 PRDTLDPAEP 2050 GEKTPVRPVT 2060 QGGSLQSPPR 2070 SPRPASVRTR 2080 KHTFGQRCVS 2090 SRPAAPGGEE 2100 AEASDPADEE 2110 VSHITSSACP 2120 WQPTAEPHGP 2130 EASPVAGGER 2140 DLRRLYSVDA 2150 QGFLDKPGRA 2160 DEQWRPSAEL 2170 GSGEPGEAKA 2180 WGPEAEPALG 2190 ARRKKKMSPP 2200 CISVEPPAED 2210 EGSARPSAAE 2220 GGSTTLRRRT 2230 PSCEATPHRD 2240 SLEPTEGSGA 2250 GGDPAAKGER 2260 WGQASCRAEH 2270 LTVPSFAFEP 2280 LDLGVPSGDP 2290 FLDGSHSVTP 2300 ESRASSSGAI 2310 VPLEPPESEP 2320 PMPVGDPPEK 2330 RRGLYLTVPQ 2340 CPLEKPGSPS 2350 ATPAPGGGAD DPV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0005891 voltage-gated calcium channel complex
Molecular Function GO:0008331 high voltage-gated calcium channel activity
Molecular Function GO:0008332 low voltage-gated calcium channel activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0097110 scaffold protein binding
Molecular Function GO:0005245 voltage-gated calcium channel activity
Molecular Function GO:0005244 voltage-gated monoatomic ion channel activity
Biological Process GO:0032342 aldosterone biosynthetic process
Biological Process GO:0070509 calcium ion import
Biological Process GO:0098703 calcium ion import across plasma membrane
Biological Process GO:0032870 cellular response to hormone stimulus
Biological Process GO:0035865 cellular response to potassium ion
Biological Process GO:0034651 cortisol biosynthetic process
Biological Process GO:0006936 muscle contraction
Biological Process GO:0007517 muscle organ development
Biological Process GO:0007520 myoblast fusion
Biological Process GO:2000344 positive regulation of acrosome reaction
Biological Process GO:0008016 regulation of heart contraction
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0055085 transmembrane transport

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.