Search Results

Overview

Uniprot IDO95197
Protein NameReticulon-3
Gene NameRTN3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1018 QTKSIVEKIQAKLPG
905 SVIQAVQKSEEGHPF
998 PIVYEKYKTQIDHYV

Function

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). Also acts as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition

Protein Sequence

10 MAEPSAATQS 20 HSISSSSFGA 30 EPSAPGGGGS 40 PGACPALGTK 50 SCSSSCADSF 60 VSSSSSQPVS 70 LFSTSQEGLS 80 SLCSDEPSSE 90 IMTSSFLSSS 100 EIHNTGLTIL 110 HGEKSHVLGS 120 QPILAKEGKD 130 HLDLLDMKKM 140 EKPQGTSNNV 150 SDSSVSLAAG 160 VHCDRPSIPA 170 SFPEHPAFLS 180 KKIGQVEEQI 190 DKETKNPNGV 200 SSREAKTALD 210 ADDRFTLLTA 220 QKPPTEYSKV 230 EGIYTYSLSP 240 SKVSGDDVIE 250 KDSPESPFEV 260 IIDKAAFDKE 270 FKDSYKESTD 280 DFGSWSVHTD 290 KESSEDISET 300 NDKLFPLRNK 310 EAGRYPMSAL 320 LSRQFSHTNA 330 ALEEVSRCVN 340 DMHNFTNEIL 350 TWDLVPQVKQ 360 QTDKSSDCIT 370 KTTGLDMSEY 380 NSEIPVVNLK 390 TSTHQKTPVC 400 SIDGSTPITK 410 STGDWAEASL 420 QQENAITGKP 430 VPDSLNSTKE 440 FSIKGVQGNM 450 QKQDDTLAEL 460 PGSPPEKCDS 470 LGSGVATVKV 480 VLPDDHLKDE 490 MDWQSSALGE 500 ITEADSSGES 510 DDTVIEDITA 520 DTSFENNKIQ 530 AEKPVSIPSA 540 VVKTGEREIK 550 EIPSCEREEK 560 TSKNFEELVS 570 DSELHQDQPD 580 ILGRSPASEA 590 ACSKVPDTNV 600 SLEDVSEVAP 610 EKPITTENPK 620 LPSTVSPNVF 630 NETEFSLNVT 640 TSAYLESLHG 650 KNVKHIDDSS 660 PEDLIAAFTE 670 TRDKGIVDSE 680 RNAFKAISEK 690 MTDFKTTPPV 700 EVLHENESGG 710 SEIKDIGSKY 720 SEQSKETNGS 730 EPLGVFPTQG 740 TPVASLDLEQ 750 EQLTIKALKE 760 LGERQVEKST 770 SAQRDAELPS 780 EEVLKQTFTF 790 APESWPQRSY 800 DILERNVKNG 810 SDLGISQKPI 820 TIRETTRVDA 830 VSSLSKTELV 840 KKHVLARLLT 850 DFSVHDLIFW 860 RDVKKTGFVF 870 GTTLIMLLSL 880 AAFSVISVVS 890 YLILALLSVT 900 ISFRIYKSVI 910 QAVQKSEEGH 920 PFKAYLDVDI 930 TLSSEAFHNY 940 MNAAMVHINR 950 ALKLIIRLFL 960 VEDLVDSLKL 970 AVFMWLMTYV 980 GAVFNGITLL 990 ILAELLIFSV 1000 PIVYEKYKTQ 1010 IDHYVGIARD 1020 QTKSIVEKIQ 1030 AKLPGIAKKK AE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0014069 postsynaptic density
Biological Process GO:0006915 apoptotic process
Biological Process GO:0007420 brain development
Biological Process GO:0071787 endoplasmic reticulum tubular network formation
Biological Process GO:1990809 endoplasmic reticulum tubular network membrane organization
Biological Process GO:0071786 endoplasmic reticulum tubular network organization
Biological Process GO:1902430 negative regulation of amyloid-beta formation
Biological Process GO:0030182 neuron differentiation
Biological Process GO:0061709 reticulophagy
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.