Search Results

Overview

Uniprot IDO95202
Protein NameMitochondrial proton/calcium exchanger protein
Gene NameLETM1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
150 PPAEVVVKKSLGQRV
373 GVDSLNVKELQAACR
451 VAKEAQVKVAEVEGE
463 EGEQVDNKAKLEATL
597 LSKTGEEKYVEESKA

Function

Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:18628306, PubMed:19797662, PubMed:24344246, PubMed:24898248, PubMed:29123128, PubMed:32139798, PubMed:36055214, PubMed:36321428). Mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662, PubMed:24344246, PubMed:29123128). Also functions as an electroneutral mitochondrial proton/potassium exchanger (PubMed:24898248, PubMed:36055214, PubMed:36321428). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306, PubMed:36055214). Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306, PubMed:32139798)

Protein Sequence

10 MASILLRSCR 20 GRAPARLPPP 30 PRYTVPRGSP 40 GDPAHLSCAS 50 TLGLRNCLNV 60 PFGCCTPIHP 70 VYTSSRGDHL 80 GCWALRPECL 90 RIVSRAPWTS 100 TSVGFVAVGP 110 QCLPVRGWHS 120 SRPVRDDSVV 130 EKSLKSLKDK 140 NKKLEEGGPV 150 YSPPAEVVVK 160 KSLGQRVLDE 170 LKHYYHGFRL 180 LWIDTKIAAR 190 MLWRILNGHS 200 LTRRERRQFL 210 RICADLFRLV 220 PFLVFVVVPF 230 MEFLLPVAVK 240 LFPNMLPSTF 250 ETQSLKEERL 260 KKELRVKLEL 270 AKFLQDTIEE 280 MALKNKAAKG 290 SATKDFSVFF 300 QKIRETGERP 310 SNEEIMRFSK 320 LFEDELTLDN 330 LTRPQLVALC 340 KLLELQSIGT 350 NNFLRFQLTM 360 RLRSIKADDK 370 LIAEEGVDSL 380 NVKELQAACR 390 ARGMRALGVT 400 EDRLRGQLKQ 410 WLDLHLHQEI 420 PTSLLILSRA 430 MYLPDTLSPA 440 DQLKSTLQTL 450 PEIVAKEAQV 460 KVAEVEGEQV 470 DNKAKLEATL 480 QEEAAIQQEH 490 REKELQKRSE 500 VAKDFEPERV 510 VAAPQRPGTE 520 PQPEMPDTVL 530 QSETLKDTAP 540 VLEGLKEEEI 550 TKEEIDILSD 560 ACSKLQEQKK 570 SLTKEKEELE 580 LLKEDVQDYS 590 EDLQEIKKEL 600 SKTGEEKYVE 610 ESKASKRLTK 620 RVQQMIGQID 630 GLISQLEMDQ 640 QAGKLAPANG 650 MPTGENVISV 660 AELINAMKQV 670 KHIPESKLTS 680 LAAALDENKD 690 GKVNIDDLVK 700 VIELVDKEDV 710 HISTSQVAEI 720 VATLEKEEKV 730 EEKEKAKEKA EKEVAEVKS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0015369 calcium:proton antiporter activity
Molecular Function GO:0043022 ribosome binding
Biological Process GO:0099093 calcium export from the mitochondrion
Biological Process GO:0006816 calcium ion transport
Biological Process GO:0042407 cristae formation
Biological Process GO:0007007 inner mitochondrial membrane organization
Biological Process GO:0051560 mitochondrial calcium ion homeostasis
Biological Process GO:0006851 mitochondrial calcium ion transmembrane transport
Biological Process GO:0140141 mitochondrial potassium ion transmembrane transport
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:0051562 negative regulation of mitochondrial calcium ion concentration
Biological Process GO:0034214 protein hexamerization
Biological Process GO:0051260 protein homooligomerization
Biological Process GO:1900069 regulation of cellular hyperosmotic salinity response

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.