Search Results
Overview
| Uniprot ID | O95210 |
|---|---|
| Protein Name | Starch-binding domain-containing protein 1 |
| Gene Name | STBD1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 164 | KGQEISAKAATCFAE |
| 172 | AATCFAEKLPSSNLL |
| 180 | LPSSNLLKNRAKEEM |
| 184 | NLLKNRAKEEMSLSD |
| 250 | RGQQVHGKMERVAVM |
| 92 | SKTKDLGKLQAASWR |
Function
Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes
Protein Sequence
10
MGAVWSALLV
20
GGGLAGALFV
30
WLLRGGPGDT
40
GKDGDAEQEK
50
DAPLGGAAIP
60
GGHQSGSSGL
70
SPGPSGQELV
80
TKPEHLQESN
90
GHLISKTKDL
100
GKLQAASWRL
110
QNPSREVCDN
120
SREHVPSGQF
130
PDTEAPATSE
140
TSNSRSYSEV
150
SRNESLESPM
160
GEWGFQKGQE
170
ISAKAATCFA
180
EKLPSSNLLK
190
NRAKEEMSLS
200
DLNSQDRVDH
210
EEWEMVPRHS
220
SWGDVGVGGS
230
LKAPVLNLNQ
240
GMDNGRSTLV
250
EARGQQVHGK
260
MERVAVMPAG
270
SQQVSVRFQV
280
HYVTSTDVQF
290
IAVTGDHECL
300
GRWNTYIPLH
310
YNKDGFWSHS
320
IFLPADTVVE
330
WKFVLVENGG
340
VTRWEECSNR
350
FLETGHEDKV
VHAWWGIH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0101003 | ficolin-1-rich granule membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0034045 | phagophore assembly site membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0030315 | T-tubule |
| Cellular Component | GO:0070821 | tertiary granule membrane |
| Molecular Function | GO:0038024 | cargo receptor activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:2001069 | glycogen binding |
| Molecular Function | GO:0030247 | polysaccharide binding |
| Molecular Function | GO:2001070 | starch binding |
| Biological Process | GO:0005980 | glycogen catabolic process |
| Biological Process | GO:0061723 | glycophagy |
| Biological Process | GO:0007041 | lysosomal transport |
| Biological Process | GO:0061753 | substrate localization to autophagosome |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.