Search Results

Overview

Uniprot IDO95218
Protein NameZinc finger Ran-binding domain-containing protein 2
Gene NameZRANB2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
137 KKKKYRGKAVGPASI
18 GDWICPDKKCGNVNF
19 DWICPDKKCGNVNFA
43 REKTTEAKMMKAGGT
46 TTEAKMMKAGGTEIG
54 AGGTEIGKTLAEKSR
59 IGKTLAEKSRGLFSA
92 CNMCNTPKYAKLEER
95 CNTPKYAKLEERTGY

Function

Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May interfere with constitutive 5'-splice site selection

Protein Sequence

10 MSTKNFRVSD 20 GDWICPDKKC 30 GNVNFARRTS 40 CNRCGREKTT 50 EAKMMKAGGT 60 EIGKTLAEKS 70 RGLFSANDWQ 80 CKTCSNVNWA 90 RRSECNMCNT 100 PKYAKLEERT 110 GYGGGFNERE 120 NVEYIEREES 130 DGEYDEFGRK 140 KKKYRGKAVG 150 PASILKEVED 160 KESEGEEEDE 170 DEDLSKYKLD 180 EDEDEDDADL 190 SKYNLDASEE 200 EDSNKKKSNR 210 RSRSKSRSSH 220 SRSSSRSSSP 230 SSSRSRSRSR 240 SRSSSSSQSR 250 SRSSSRERSR 260 SRGSKSRSSS 270 RSHRGSSSPR 280 KRSYSSSSSS 290 PERNRKRSRS 300 RSSSSGDRKK 310 RRTRSRSPER 320 RHRSSSGSSH 330 SGSRSSSKKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0001530 lipopolysaccharide binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006397 mRNA processing
Biological Process GO:0008380 RNA splicing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[7] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[8] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[9] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[10] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[11] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[12] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.