Search Results
Overview
| Uniprot ID | O95219 |
|---|---|
| Protein Name | Sorting nexin-4 |
| Gene Name | SNX4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 188 | LTQEGNWKETVNETG |
Function
Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730, PubMed:17994011, PubMed:32513819, PubMed:33468622). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (PubMed:17994011). Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A (PubMed:32513819, PubMed:33468622)
Protein Sequence
10
MEQAPPDPER
20
QLQPAPLEPL
30
GSPDAGLGAA
40
VGKEAEGAGE
50
ESSGVDTMTH
60
NNFWLKKIEI
70
SVSEAEKRTG
80
RNAMNMQETY
90
TAYLIETRSV
100
EHTDGQSVLT
110
DSLWRRYSEF
120
ELLRSYLLVY
130
YPHIVVPPLP
140
EKRAEFVWHK
150
LSADNMDPDF
160
VERRRIGLEN
170
FLLRIASHPI
180
LCRDKIFYLF
190
LTQEGNWKET
200
VNETGFQLKA
210
DSRLKALNAT
220
FRVKNPDKRF
230
TDLKHYSDEL
240
QSVISHLLRV
250
RARVADRLYG
260
VYKVHGNYGR
270
VFSEWSAIEK
280
EMGDGLQSAG
290
HHMDVYASSI
300
DDILEDEEHY
310
ADQLKEYLFY
320
AEALRAVCRK
330
HELMQYDLEM
340
AAQDLASKKQ
350
QCEELVTGTV
360
RTFSLKGMTT
370
KLFGQETPEQ
380
REARIKVLEE
390
QINEGEQQLK
400
SKNLEGREFV
410
KNAWADIERF
420
KEQKNRDLKE
430
ALISYAVMQI
440
SMCKKGIQVW
450
TNAKECFSKM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005868 | cytoplasmic dynein complex |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098830 | presynaptic endosome |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0031201 | SNARE complex |
| Molecular Function | GO:0005154 | epidermal growth factor receptor binding |
| Molecular Function | GO:0005158 | insulin receptor binding |
| Molecular Function | GO:1990460 | leptin receptor binding |
| Molecular Function | GO:0035091 | phosphatidylinositol binding |
| Molecular Function | GO:0032266 | phosphatidylinositol-3-phosphate binding |
| Molecular Function | GO:1990459 | transferrin receptor binding |
| Biological Process | GO:0032456 | endocytic recycling |
| Biological Process | GO:2000786 | positive regulation of autophagosome assembly |
| Biological Process | GO:1903595 | positive regulation of histamine secretion by mast cell |
| Biological Process | GO:0015031 | protein transport |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.