Search Results

Overview

Uniprot IDO95239
Protein NameChromosome-associated kinesin KIF4A
Gene NameKIF4A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1033 KPSRVKEKFLEQSMD
1077 WKPTKLVKVSRKNIQ
1081 KLVKVSRKNIQGCSC
1179 DVEQVLSKKTPPAPS
1180 VEQVLSKKTPPAPSP
1204 ATEYQENKAPGKKKK
1209 ENKAPGKKKKRALAS
536 LNKALALKEALARKM
587 LELQTAKKDANQAKL
593 KKDANQAKLSERRRK
676 DKEVIQLKERDRKRQ
688 KRQYELLKLERNFQK
794 SGENPPPKLRRRTFS

Function

Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity)

Protein Sequence

10 MKEEVKGIPV 20 RVALRCRPLV 30 PKEISEGCQM 40 CLSFVPGEPQ 50 VVVGTDKSFT 60 YDFVFDPSTE 70 QEEVFNTAVA 80 PLIKGVFKGY 90 NATVLAYGQT 100 GSGKTYSMGG 110 AYTAEQENEP 120 TVGVIPRVIQ 130 LLFKEIDKKS 140 DFEFTLKVSY 150 LEIYNEEILD 160 LLCPSREKAQ 170 INIREDPKEG 180 IKIVGLTEKT 190 VLVALDTVSC 200 LEQGNNSRTV 210 ASTAMNSQSS 220 RSHAIFTISL 230 EQRKKSDKNS 240 SFRSKLHLVD 250 LAGSERQKKT 260 KAEGDRLKEG 270 ININRGLLCL 280 GNVISALGDD 290 KKGGFVPYRD 300 SKLTRLLQDS 310 LGGNSHTLMI 320 ACVSPADSNL 330 EETLNTLRYA 340 DRARKIKNKP 350 IVNIDPQTAE 360 LNHLKQQVQQ 370 LQVLLLQAHG 380 GTLPGSITVE 390 PSENLQSLME 400 KNQSLVEENE 410 KLSRGLSEAA 420 GQTAQMLERI 430 ILTEQANEKM 440 NAKLEELRQH 450 AACKLDLQKL 460 VETLEDQELK 470 ENVEIICNLQ 480 QLITQLSDET 490 VACMAAAIDT 500 AVEQEAQVET 510 SPETSRSSDA 520 FTTQHALRQA 530 QMSKELVELN 540 KALALKEALA 550 RKMTQNDSQL 560 QPIQYQYQDN 570 IKELELEVIN 580 LQKEKEELVL 590 ELQTAKKDAN 600 QAKLSERRRK 610 RLQELEGQIA 620 DLKKKLNEQS 630 KLLKLKESTE 640 RTVSKLNQEI 650 RMMKNQRVQL 660 MRQMKEDAEK 670 FRQWKQKKDK 680 EVIQLKERDR 690 KRQYELLKLE 700 RNFQKQSNVL 710 RRKTEEAAAA 720 NKRLKDALQK 730 QREVADKRKE 740 TQSRGMEGTA 750 ARVKNWLGNE 760 IEVMVSTEEA 770 KRHLNDLLED 780 RKILAQDVAQ 790 LKEKKESGEN 800 PPPKLRRRTF 810 SLTEVRGQVS 820 ESEDSITKQI 830 ESLETEMEFR 840 SAQIADLQQK 850 LLDAESEDRP 860 KQRWENIATI 870 LEAKCALKYL 880 IGELVSSKIQ 890 VSKLESSLKQ 900 SKTSCADMQK 910 MLFEERNHFA 920 EIETELQAEL 930 VRMEQQHQEK 940 VLYLLSQLQQ 950 SQMAEKQLEE 960 SVSEKEQQLL 970 STLKCQDEEL 980 EKMREVCEQN 990 QQLLRENEII 1000 KQKLTLLQVA 1010 SRQKHLPKDT 1020 LLSPDSSFEY 1030 VPPKPKPSRV 1040 KEKFLEQSMD 1050 IEDLKYCSEH 1060 SVNEHEDGDG 1070 DDDEGDDEEW 1080 KPTKLVKVSR 1090 KNIQGCSCKG 1100 WCGNKQCGCR 1110 KQKSDCGVDC 1120 CCDPTKCRNR 1130 QQGKDSLGTV 1140 ERTQDSEGSF 1150 KLEDPTEVTP 1160 GLSFFNPVCA 1170 TPNSKILKEM 1180 CDVEQVLSKK 1190 TPPAPSPFDL 1200 PELKHVATEY 1210 QENKAPGKKK 1220 KRALASNTSF 1230 FSGCSPIEEE AH

Gene Ontology

Classification GO ID Description
Cellular Component GO:1904115 axon cytoplasm
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005875 microtubule associated complex
Cellular Component GO:0030496 midbody
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005876 spindle microtubule
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0051536 iron-sulfur cluster binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0003777 microtubule motor activity
Biological Process GO:0008089 anterograde axonal transport
Biological Process GO:0000281 mitotic cytokinesis
Biological Process GO:0051256 mitotic spindle midzone assembly
Biological Process GO:0007052 mitotic spindle organization
Biological Process GO:0006996 organelle organization
Biological Process GO:0051231 spindle elongation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.