Search Results

Overview

Uniprot ID	O95255
Protein Name	ATP-binding cassette sub-family C member 6
Gene Name	ABCC6
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
872	TEPGTSTKDPRGTSA

Function

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed:11880368, PubMed:12414644). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin (PubMed:12414644)

Protein Sequence

10 MAAPAEPCAG 20 QGVWNQTEPE 30 PAATSLLSLC 40 FLRTAGVWVP 50 PMYLWVLGPI 60 YLLFIHHHGR 70 GYLRMSPLFK 80 AKMVLGFALI 90 VLCTSSVAVA 100 LWKIQQGTPE 110 APEFLIHPTV 120 WLTTMSFAVF 130 LIHTERKKGV 140 QSSGVLFGYW 150 LLCFVLPATN 160 AAQQASGAGF 170 QSDPVRHLST 180 YLCLSLVVAQ 190 FVLSCLADQP 200 PFFPEDPQQS 210 NPCPETGAAF 220 PSKATFWWVS 230 GLVWRGYRRP 240 LRPKDLWSLG 250 RENSSEELVS 260 RLEKEWMRNR 270 SAARRHNKAI 280 AFKRKGGSGM 290 KAPETEPFLR 300 QEGSQWRPLL 310 KAIWQVFHST 320 FLLGTLSLII 330 SDVFRFTVPK 340 LLSLFLEFIG 350 DPKPPAWKGY 360 LLAVLMFLSA 370 CLQTLFEQQN 380 MYRLKVLQMR 390 LRSAITGLVY 400 RKVLALSSGS 410 RKASAVGDVV 420 NLVSVDVQRL 430 TESVLYLNGL 440 WLPLVWIVVC 450 FVYLWQLLGP 460 SALTAIAVFL 470 SLLPLNFFIS 480 KKRNHHQEEQ 490 MRQKDSRARL 500 TSSILRNSKT 510 IKFHGWEGAF 520 LDRVLGIRGQ 530 ELGALRTSGL 540 LFSVSLVSFQ 550 VSTFLVALVV 560 FAVHTLVAEN 570 AMNAEKAFVT 580 LTVLNILNKA 590 QAFLPFSIHS 600 LVQARVSFDR 610 LVTFLCLEEV 620 DPGVVDSSSS 630 GSAAGKDCIT 640 IHSATFAWSQ 650 ESPPCLHRIN 660 LTVPQGCLLA 670 VVGPVGAGKS 680 SLLSALLGEL 690 SKVEGFVSIE 700 GAVAYVPQEA 710 WVQNTSVVEN 720 VCFGQELDPP 730 WLERVLEACA 740 LQPDVDSFPE 750 GIHTSIGEQG 760 MNLSGGQKQR 770 LSLARAVYRK 780 AAVYLLDDPL 790 AALDAHVGQH 800 VFNQVIGPGG 810 LLQGTTRILV 820 THALHILPQA 830 DWIIVLANGA 840 IAEMGSYQEL 850 LQRKGALMCL 860 LDQARQPGDR 870 GEGETEPGTS 880 TKDPRGTSAG 890 RRPELRRERS 900 IKSVPEKDRT 910 TSEAQTEVPL 920 DDPDRAGWPA 930 GKDSIQYGRV 940 KATVHLAYLR 950 AVGTPLCLYA 960 LFLFLCQQVA 970 SFCRGYWLSL 980 WADDPAVGGQ 990 QTQAALRGGI 1000 FGLLGCLQAI 1010 GLFASMAAVL 1020 LGGARASRLL 1030 FQRLLWDVVR 1040 SPISFFERTP 1050 IGHLLNRFSK 1060 ETDTVDVDIP 1070 DKLRSLLMYA 1080 FGLLEVSLVV 1090 AVATPLATVA 1100 ILPLFLLYAG 1110 FQSLYVVSSC 1120 QLRRLESASY 1130 SSVCSHMAET 1140 FQGSTVVRAF 1150 RTQAPFVAQN 1160 NARVDESQRI 1170 SFPRLVADRW 1180 LAANVELLGN 1190 GLVFAAATCA 1200 VLSKAHLSAG 1210 LVGFSVSAAL 1220 QVTQTLQWVV 1230 RNWTDLENSI 1240 VSVERMQDYA 1250 WTPKEAPWRL 1260 PTCAAQPPWP 1270 QGGQIEFRDF 1280 GLRYRPELPL 1290 AVQGVSFKIH 1300 AGEKVGIVGR 1310 TGAGKSSLAS 1320 GLLRLQEAAE 1330 GGIWIDGVPI 1340 AHVGLHTLRS 1350 RISIIPQDPI 1360 LFPGSLRMNL 1370 DLLQEHSDEA 1380 IWAALETVQL 1390 KALVASLPGQ 1400 LQYKCADRGE 1410 DLSVGQKQLL 1420 CLARALLRKT 1430 QILILDEATA 1440 AVDPGTELQM 1450 QAMLGSWFAQ 1460 CTVLLIAHRL 1470 RSVMDCARVL 1480 VMDKGQVAES 1490 GSPAQLLAQK 1500 GLFYRLAQES GLV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0009925	basal plasma membrane
Cellular Component	GO:0016323	basolateral plasma membrane
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0015431	ABC-type glutathione S-conjugate transporter activity
Molecular Function	GO:0140359	ABC-type transporter activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity
Biological Process	GO:0046034	ATP metabolic process
Biological Process	GO:0015867	ATP transport
Biological Process	GO:0055074	calcium ion homeostasis
Biological Process	GO:0010467	gene expression
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization
Biological Process	GO:0030505	inorganic diphosphate transport
Biological Process	GO:0030643	intracellular phosphate ion homeostasis
Biological Process	GO:0071716	leukotriene transport
Biological Process	GO:0055062	phosphate ion homeostasis
Biological Process	GO:0032026	response to magnesium ion
Biological Process	GO:1904383	response to sodium phosphate
Biological Process	GO:0009410	response to xenobiotic stimulus
Biological Process	GO:0055085	transmembrane transport
Biological Process	GO:0007601	visual perception

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.