Overview
| Uniprot ID | O95259 |
|---|
| Protein Name | Voltage-gated delayed rectifier potassium channel KCNH1 |
|---|
| Gene Name | KCNH1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 561 |
KVLQICPKDMRADIC |
Function
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate (PubMed:10880439, PubMed:11943152, PubMed:22732247, PubMed:25420144, PubMed:25556795, PubMed:25915598, PubMed:27005320, PubMed:27325704, PubMed:27618660, PubMed:30149017, PubMed:9738473). The activation kinetics depend on the prepulse potential and external divalent cation concentration (PubMed:11943152). With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation (PubMed:11943152). The time course of activation is biphasic with a fast and a slowly activating current component (PubMed:11943152). Activates at more positive membrane potentials and exhibit a steeper activation curve (PubMed:11943152). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642)
Protein Sequence
10
MTMAGGRRGL
20
VAPQNTFLEN
30
IVRRSNDTNF
40
VLGNAQIVDW
50
PIVYSNDGFC
60
KLSGYHRAEV
70
MQKSSTCSFM
80
YGELTDKDTI
90
EKVRQTFENY
100
EMNSFEILMY
110
KKNRTPVWFF
120
VKIAPIRNEQ
130
DKVVLFLCTF
140
SDITAFKQPI
150
EDDSCKGWGK
160
FARLTRALTS
170
SRGVLQQLAP
180
SVQKGENVHK
190
HSRLAEVLQL
200
GSDILPQYKQ
210
EAPKTPPHII
220
LHYCVFKTTW
230
DWIILILTFY
240
TAILVPYNVS
250
FKTRQNNVAW
260
LVVDSIVDVI
270
FLVDIVLNFH
280
TTFVGPAGEV
290
ISDPKLIRMN
300
YLKTWFVIDL
310
LSCLPYDVIN
320
AFENVDEVSA
330
FMGDPGKIGF
340
ADQIPPPLEG
350
RESQGISSLF
360
SSLKVVRLLR
370
LGRVARKLDH
380
YIEYGAAVLV
390
LLVCVFGLAA
400
HWMACIWYSI
410
GDYEIFDEDT
420
KTIRNNSWLY
430
QLAMDIGTPY
440
QFNGSGSGKW
450
EGGPSKNSVY
460
ISSLYFTMTS
470
LTSVGFGNIA
480
PSTDIEKIFA
490
VAIMMIGSLL
500
YATIFGNVTT
510
IFQQMYANTN
520
RYHEMLNSVR
530
DFLKLYQVPK
540
GLSERVMDYI
550
VSTWSMSRGI
560
DTEKVLQICP
570
KDMRADICVH
580
LNRKVFKEHP
590
AFRLASDGCL
600
RALAMEFQTV
610
HCAPGDLIYH
620
AGESVDSLCF
630
VVSGSLEVIQ
640
DDEVVAILGK
650
GDVFGDVFWK
660
EATLAQSCAN
670
VRALTYCDLH
680
VIKRDALQKV
690
LEFYTAFSHS
700
FSRNLILTYN
710
LRKRIVFRKI
720
SDVKREEEER
730
MKRKNEAPLI
740
LPPDHPVRRL
750
FQRFRQQKEA
760
RLAAERGGRD
770
LDDLDVEKGN
780
VLTEHASANH
790
SLVKASVVTV
800
RESPATPVSF
810
QAASTSGVPD
820
HAKLQAPGSE
830
CLGPKGGGGD
840
CAKRKSWARF
850
KDACGKSEDW
860
NKVSKAESME
870
TLPERTKASG
880
EATLKKTDSC
890
DSGITKSDLR
900
LDNVGEARSP
910
QDRSPILAEV
920
KHSFYPIPEQ
930
TLQATVLEVR
940
HELKEDIKAL
950
NAKMTNIEKQ
960
LSEILRILTS
970
RRSSQSPQEL
980
FEISRPQSPE
SERDIFGAS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030424 |
axon |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Cellular Component |
GO:0005637 |
nuclear inner membrane |
| Cellular Component |
GO:0043204 |
perikaryon |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0098839 |
postsynaptic density membrane |
| Cellular Component |
GO:0042734 |
presynaptic membrane |
| Cellular Component |
GO:0008076 |
voltage-gated potassium channel complex |
| Molecular Function |
GO:0005516 |
calmodulin binding |
| Molecular Function |
GO:0005251 |
delayed rectifier potassium channel activity |
| Molecular Function |
GO:1902936 |
phosphatidylinositol bisphosphate binding |
| Biological Process |
GO:0071277 |
cellular response to calcium ion |
| Biological Process |
GO:0007520 |
myoblast fusion |
| Biological Process |
GO:0071805 |
potassium ion transmembrane transport |
| Biological Process |
GO:0006813 |
potassium ion transport |
| Biological Process |
GO:0042127 |
regulation of cell population proliferation |
| Biological Process |
GO:0042391 |
regulation of membrane potential |
| Biological Process |
GO:0099509 |
regulation of presynaptic cytosolic calcium ion concentration |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.