Overview
| Uniprot ID | O95267 |
|---|
| Protein Name | RAS guanyl-releasing protein 1 |
|---|
| Gene Name | RASGRP1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 783 |
IESLQLEKSNHVLAQ |
Function
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768, PubMed:27776107, PubMed:29155103). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994, PubMed:27776107, PubMed:29155103). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types (PubMed:12845332)
Protein Sequence
10
MGTLGKAREA
20
PRKPSHGCRA
30
ASKARLEAKP
40
ANSPFPSHPS
50
LAHITQFRMM
60
VSLGHLAKGA
70
SLDDLIDSCI
80
QSFDADGNLC
90
RSNQLLQVML
100
TMHRIVISSA
110
ELLQKVITLY
120
KDALAKNSPG
130
LCLKICYFVR
140
YWITEFWVMF
150
KMDASLTDTM
160
EEFQELVKAK
170
GEELHCRLID
180
TTQINARDWS
190
RKLTQRIKSN
200
TSKKRKVSLL
210
FDHLEPEELS
220
EHLTYLEFKS
230
FRRISFSDYQ
240
NYLVNSCVKE
250
NPTMERSIAL
260
CNGISQWVQL
270
MVLSRPTPQL
280
RAEVFIKFIQ
290
VAQKLHQLQN
300
FNTLMAVIGG
310
LCHSSISRLK
320
ETSSHVPHEI
330
NKVLGEMTEL
340
LSSSRNYDNY
350
RRAYGECTDF
360
KIPILGVHLK
370
DLISLYEAMP
380
DYLEDGKVNV
390
HKLLALYNHI
400
SELVQLQEVA
410
PPLEANKDLV
420
HLLTLSLDLY
430
YTEDEIYELS
440
YAREPRNHRA
450
PPLTPSKPPV
460
VVDWASGVSP
470
KPDPKTISKH
480
VQRMVDSVFK
490
NYDHDQDGYI
500
SQEEFEKIAA
510
SFPFSFCVMD
520
KDREGLISRD
530
EITAYFMRAS
540
SIYSKLGLGF
550
PHNFQETTYL
560
KPTFCDNCAG
570
FLWGVIKQGY
580
RCKDCGMNCH
590
KQCKDLVVFE
600
CKKRAKNPVA
610
PTENNTSVGP
620
VSNLCSLGAK
630
DLLHAPEEGP
640
FTFPNGEAVE
650
HGEESKDRTI
660
MLMGVSSQKI
670
SLRLKRAVAH
680
KATQTESQPW
690
IGSEGPSGPF
700
VLSSPRKTAQ
710
DTLYVLPSPT
720
SPCPSPVLVR
730
KRAFVKWENK
740
DSLIKSKEEL
750
RHLRLPTYQE
760
LEQEINTLKA
770
DNDALKIQLK
780
YAQKKIESLQ
790
LEKSNHVLAQ
MEQGDCS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0019992 |
diacylglycerol binding |
| Molecular Function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0008289 |
lipid binding |
| Molecular Function |
GO:0031210 |
phosphatidylcholine binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0090630 |
activation of GTPase activity |
| Biological Process |
GO:0042113 |
B cell activation |
| Biological Process |
GO:0042100 |
B cell proliferation |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0030101 |
natural killer cell activation |
| Biological Process |
GO:0043406 |
positive regulation of MAP kinase activity |
| Biological Process |
GO:0032825 |
positive regulation of natural killer cell differentiation |
| Biological Process |
GO:0045954 |
positive regulation of natural killer cell mediated cytotoxicity |
| Biological Process |
GO:0001934 |
positive regulation of protein phosphorylation |
| Biological Process |
GO:0046579 |
positive regulation of Ras protein signal transduction |
| Biological Process |
GO:0033089 |
positive regulation of T cell differentiation in thymus |
| Biological Process |
GO:0007265 |
Ras protein signal transduction |
| Biological Process |
GO:0070372 |
regulation of ERK1 and ERK2 cascade |
| Biological Process |
GO:0007165 |
signal transduction |
| Biological Process |
GO:0042110 |
T cell activation |
| Biological Process |
GO:0042098 |
T cell proliferation |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.