Search Results
Overview
| Uniprot ID | O95298 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] 1 subunit C2 |
| Gene Name | NDUFC2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | TYGEIFEKFHPIR** |
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis but required for the complex assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Protein Sequence
10
MIARRNPEPL
20
RFLPDEARSL
30
PPPKLTDPRL
40
LYIGFLGYCS
50
GLIDNLIRRR
60
PIATAGLHRQ
70
LLYITAFFFA
80
GYYLVKREDY
90
LYAVRDREMF
100
GYMKLHPEDF
110
PEEDKKTYGE
IFEKFHPIR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035577 | azurophil granule membrane |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Molecular Function | GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
| Biological Process | GO:0009060 | aerobic respiration |
| Biological Process | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
| Biological Process | GO:0032981 | mitochondrial respiratory chain complex I assembly |
| Biological Process | GO:1901223 | negative regulation of non-canonical NF-kappaB signal transduction |
| Biological Process | GO:1903427 | negative regulation of reactive oxygen species biosynthetic process |
| Biological Process | GO:2001171 | positive regulation of ATP biosynthetic process |
| Biological Process | GO:0010918 | positive regulation of mitochondrial membrane potential |
| Biological Process | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.