Overview
| Uniprot ID | O95319 |
|---|
| Protein Name | CUGBP Elav-like family member 2 |
|---|
| Gene Name | CELF2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 458 |
SAKVFIDKQTNLSKC |
Function
RNA-binding protein implicated in the regulation of several post-transcriptional events (PubMed:11577082, PubMed:11158314, PubMed:11931771, PubMed:12649496, PubMed:14973222, PubMed:15657417). Involved in pre-mRNA alternative splicing, mRNA translation and stability (PubMed:11158314, PubMed:11931771, PubMed:12649496, PubMed:14973222, PubMed:15657417, PubMed:15894795). Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing (PubMed:11158314, PubMed:11931771, PubMed:12649496). Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle (PubMed:11158314, PubMed:11931771). Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB (PubMed:11931771). Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs (PubMed:12649496). Promotes inclusion of exon 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA (By similarity). Involved in the apoB RNA editing activity (PubMed:11577082). Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5 (PubMed:11158314). Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs (PubMed:11931771, PubMed:15657417). Binds to apoB mRNA, specifically to AU-rich sequences located immediately upstream of the edited cytidine (PubMed:11577082). Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (PubMed:11158314). May be a specific regulator of miRNA biogenesis (PubMed:28431233). Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA (PubMed:28431233)
Protein Sequence
10
MRCPKSAVTM
20
RNEELLLSNG
30
TANKMNGALD
40
HSDQPDPDAI
50
KMFVGQIPRS
60
WSEKELKELF
70
EPYGAVYQIN
80
VLRDRSQNPP
90
QSKGCCFVTF
100
YTRKAALEAQ
110
NALHNIKTLP
120
GMHHPIQMKP
130
ADSEKSNAVE
140
DRKLFIGMVS
150
KKCNENDIRV
160
MFSPFGQIEE
170
CRILRGPDGL
180
SRGCAFVTFS
190
TRAMAQNAIK
200
AMHQSQTMEG
210
CSSPIVVKFA
220
DTQKDKEQRR
230
LQQQLAQQMQ
240
QLNTATWGNL
250
TGLGGLTPQY
260
LALLQQATSS
270
SNLGAFSGIQ
280
QMAGMNALQL
290
QNLATLAAAA
300
AAAQTSATST
310
NANPLSTTSS
320
ALGALTSPVA
330
ASTPNSTAGA
340
AMNSLTSLGT
350
LQGLAGATVG
360
LNNINALAGM
370
AALNGGLGAT
380
GLTNGTAGTM
390
DALTQAYSGI
400
QQYAAAALPT
410
LYSQSLLQQQ
420
SAAGSQKEGP
430
EGANLFIYHL
440
PQEFGDQDIL
450
QMFMPFGNVI
460
SAKVFIDKQT
470
NLSKCFGFVS
480
YDNPVSAQAA
490
IQAMNGFQIG
500
MKRLKVQLKR
SKNDSKPY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:1990904 |
ribonucleoprotein complex |
| Molecular Function |
GO:0003730 |
mRNA 3'-UTR binding |
| Molecular Function |
GO:0036002 |
pre-mRNA binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0006376 |
mRNA splice site recognition |
| Biological Process |
GO:0000381 |
regulation of alternative mRNA splicing, via spliceosome |
| Biological Process |
GO:0008016 |
regulation of heart contraction |
| Biological Process |
GO:0006396 |
RNA processing |
Reference
PMID: N/A