Search Results

Overview

Uniprot ID	O95336
Protein Name	6-phosphogluconolactonase
Gene Name	PGLS
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
180	APISDSPKPPPQRVT
208	FVATGEGKAAVLKRI

Function

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate

Protein Sequence

10 MAAPAPGLIS 20 VFSSSQELGA 30 ALAQLVAQRA 40 ACCLAGARAR 50 FALGLSGGSL 60 VSMLARELPA 70 AVAPAGPASL 80 ARWTLGFCDE 90 RLVPFDHAES 100 TYGLYRTHLL 110 SRLPIPESQV 120 ITINPELPVE 130 EAAEDYAKKL 140 RQAFQGDSIP 150 VFDLLILGVG 160 PDGHTCSLFP 170 DHPLLQEREK 180 IVAPISDSPK 190 PPPQRVTLTL 200 PVLNAARTVI 210 FVATGEGKAA 220 VLKRILEDQE 230 ENPLPAALVQ 240 PHTGKLCWFL 250 DEAAARLLTV PFEKHSTL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0017057	6-phosphogluconolactonase activity
Biological Process	GO:0005975	carbohydrate metabolic process
Biological Process	GO:0006098	pentose-phosphate shunt
Biological Process	GO:0009051	pentose-phosphate shunt, oxidative branch

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.