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Overview

Uniprot IDO95347
Protein NameStructural maintenance of chromosomes protein 2
Gene NameSMC2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1160 ANVLFKTKFVDGVST
321 QSAFDLKKKNLACEE
493 SRDIGRLKETYEALL
515 FAYKDPEKNWNRNCV

Function

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases

Protein Sequence

10 MHIKSIILEG 20 FKSYAQRTEV 30 NGFDPLFNAI 40 TGLNGSGKSN 50 ILDSICFLLG 60 ISNLSQVRAS 70 NLQDLVYKNG 80 QAGITKASVS 90 ITFDNSDKKQ 100 SPLGFEVHDE 110 ITVTRQVVIG 120 GRNKYLINGV 130 NANNTRVQDL 140 FCSVGLNVNN 150 PHFLIMQGRI 160 TKVLNMKPPE 170 ILSMIEEAAG 180 TRMYEYKKIA 190 AQKTIEKKEA 200 KLKEIKTILE 210 EEITPTIQKL 220 KEERSSYLEY 230 QKVMREIEHL 240 SRLYIAYQFL 250 LAEDTKVRSA 260 EELKEMQDKV 270 IKLQEELSEN 280 DKKIKALNHE 290 IEELEKRKDK 300 ETGGILRSLE 310 DALAEAQRVN 320 TKSQSAFDLK 330 KKNLACEESK 340 RKELEKNMVE 350 DSKTLAAKEK 360 EVKKITDGLH 370 ALQEASNKDA 380 EALAAAQQHF 390 NAVSAGLSSN 400 EDGAEATLAG 410 QMMACKNDIS 420 KAQTEAKQAQ 430 MKLKHAQQEL 440 KNKQAEVKKM 450 DSGYRKDQEA 460 LEAVKRLKEK 470 LEAEMKKLNY 480 EENKEESLLE 490 KRRQLSRDIG 500 RLKETYEALL 510 ARFPNLRFAY 520 KDPEKNWNRN 530 CVKGLVASLI 540 SVKDTSATTA 550 LELVAGERLY 560 NVVVDTEVTG 570 KKLLERGELK 580 RRYTIIPLNK 590 ISARCIAPET 600 LRVAQNLVGP 610 DNVHVALSLV 620 EYKPELQKAM 630 EFVFGTTFVC 640 DNMDNAKKVA 650 FDKRIMTRTV 660 TLGGDVFDPH 670 GTLSGGARSQ 680 AASILTKFQE 690 LKDVQDELRI 700 KENELRALEE 710 ELAGLKNTAE 720 KYRQLKQQWE 730 MKTEEADLLQ 740 TKLQQSSYHK 750 QQEELDALKK 760 TIEESEETLK 770 NTKEIQRKAE 780 EKYEVLENKM 790 KNAEAERERE 800 LKDAQKKLDC 810 AKTKADASSK 820 KMKEKQQEVE 830 AITLELEELK 840 REHTSYKQQL 850 EAVNEAIKSY 860 ESQIEVMAAE 870 VAKNKESVNK 880 AQEEVTKQKE 890 VITAQDTVIK 900 AKYAEVAKHK 910 EQNNDSQLKI 920 KELDHNISKH 930 KREAEDGAAK 940 VSKMLKDYDW 950 INAERHLFGQ 960 PNSAYDFKTN 970 NPKEAGQRLQ 980 KLQEMKEKLG 990 RNVNMRAMNV 1000 LTEAEERYND 1010 LMKKKRIVEN 1020 DKSKILTTIE 1030 DLDQKKNQAL 1040 NIAWQKVNKD 1050 FGSIFSTLLP 1060 GANAMLAPPE 1070 GQTVLDGLEF 1080 KVALGNTWKE 1090 NLTELSGGQR 1100 SLVALSLILS 1110 MLLFKPAPIY 1120 ILDEVDAALD 1130 LSHTQNIGQM 1140 LRTHFTHSQF 1150 IVVSLKEGMF 1160 NNANVLFKTK 1170 FVDGVSTVAR 1180 FTQCQNGKIS 1190 KEAKSKAKPP KGAHVEV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000793 condensed chromosome
Cellular Component GO:0000794 condensed nuclear chromosome
Cellular Component GO:0000796 condensin complex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0000228 nuclear chromosome
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003697 single-stranded DNA binding
Biological Process GO:0030183 B cell differentiation
Biological Process GO:0051301 cell division
Biological Process GO:0021987 cerebral cortex development
Biological Process GO:0071707 immunoglobulin heavy chain V-D-J recombination
Biological Process GO:0007076 mitotic chromosome condensation
Biological Process GO:1905821 positive regulation of chromosome condensation
Biological Process GO:0051984 positive regulation of chromosome segregation
Biological Process GO:1905820 positive regulation of chromosome separation

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.