Search Results

Overview

Uniprot IDO95359
Protein NameTransforming acidic coiled-coil-containing protein 2
Gene NameTACC2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2427 KKKKTPLKTDTFRVK

Function

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker

Protein Sequence

10 MGNENSTSDN 20 QRTLSAQTPR 30 SAQPPGNSQN 40 IKRKQQDTPG 50 SPDHRDASSI 60 GSVGLGGFCT 70 ASESSASLDP 80 CLVSPEVTEP 90 RKDPQGARGP 100 EGSLLPSPPP 110 SQEREHPSSS 120 MPFAECPPEG 130 CLASPAAAPE 140 DGPQTQSPRR 150 EPAPNAPGDI 160 AAAFPAERDS 170 STPYQEIAAV 180 PSAGRERQPK 190 EEGQKSSFSF 200 SSGIDQSPGM 210 SPVPLREPMK 220 APLCGEGDQP 230 GGFESQEKEA 240 AGGFPPAESR 250 QGVASVQVTP 260 EAPAAAQQGT 270 ESSAVLEKSP 280 LKPMAPIPQD 290 PAPRASDRER 300 GQGEAPPQYL 310 TDDLEFLRAC 320 HLPRSNSGAA 330 PEAEVNAASQ 340 ESCQQPVGAY 350 LPHAELPWGL 360 PSPALVPEAG 370 GSGKEALDTI 380 DVQGHPQTGM 390 RGTKPNQVVC 400 VAAGGQPEGG 410 LPVSPEPSLL 420 TPTEEAHPAS 430 SLASFPAAQI 440 PIAVEEPGSS 450 SRESVSKAGM 460 PVSADAAKEV 470 VDAGLVGLER 480 QVSDLGSKGE 490 HPEGDPGEVP 500 APSPQERGEH 510 LNTEQSHEVQ 520 PGVPPPPLPK 530 EQSHEVQPGA 540 PPPPLPKAPS 550 ESARGPPGPT 560 DGAKVHEDST 570 SPAVAKEGSR 580 SPGDSPGGKE 590 EAPEPPDGGD 600 PGNLQGEDSQ 610 AFSSKRDPEV 620 GKDELSKPSS 630 DAESRDHPSS 640 HSAQPPRKGG 650 AGHTDGPHSQ 660 TAEADASGLP 670 HKLGEEDPVL 680 PPVPDGAGEP 690 TVPEGAIWEG 700 SGLQPKCPDT 710 LQSREGLGRM 720 ESFLTLESEK 730 SDFPPTPVAE 740 VAPKAQEGES 750 TLEIRKMGSC 760 DGEGLLTSPD 770 QPRGPACDAS 780 RQEFHAGVPH 790 PPQGENLAAD 800 LGLTALILDQ 810 DQQGIPSCPG 820 EGWIRGAASE 830 WPLLSSEKHL 840 QPSQAQPETS 850 IFDVLKEQAQ 860 PPENGKETSP 870 SHPGFKDQGA 880 DSSQIHVPVE 890 PQEDNNLPTH 900 GGQEQALGSE 910 LQSQLPKGTL 920 SDTPTSSPTD 930 MVWESSLTEE 940 SELSAPTRQK 950 LPALGEKRPE 960 GACGDGQSSR 970 VSPPAADVLK 980 DFSLAGNFSR 990 KETCCTGQGP 1000 NKSQQALADA 1010 LEEGSQHEEA 1020 CQRHPGASEA 1030 ADGCSPLWGL 1040 SKREMASGNT 1050 GEAPPCQPDS 1060 VALLDAVPCL 1070 PALAPASPGV 1080 TPTQDAPETE 1090 ACDETQEGRQ 1100 QPVPAPQQKM 1110 ECWATSDAES 1120 PKLLASFPSA 1130 GEQGGEAGAA 1140 ETGGSAGAGD 1150 PGKQQAPEKP 1160 GEATLSCGLL 1170 QTEHCLTSGE 1180 EASTSALRES 1190 CQAEHPMASC 1200 QDALLPAREL 1210 GGIPRSTMDF 1220 STHQAVPDPK 1230 ELLLSGPPEV 1240 AAPDTPYLHV 1250 DSAAQRGAED 1260 SGVKAVSSAD 1270 PRAPGESPCP 1280 VGEPPLALEN 1290 AASLKLFAGS 1300 LAPLLQPGAA 1310 GGEIPAVQAS 1320 SGSPKARTTE 1330 GPVDSMPCLD 1340 RMPLLAKGKQ 1350 ATGEEKAATA 1360 PGAGAKASGE 1370 GMAGDAAGET 1380 EGSMERMGEP 1390 SQDPKQGTSG 1400 GVDTSSEQIA 1410 TLTGFPDFRE 1420 HIAKIFEKPV 1430 LGALATPGEK 1440 AGAGRSAVGK 1450 DLTRPLGPEK 1460 LLDGPPGVDV 1470 TLLPAPPARL 1480 QVEKKQQLAG 1490 EAEISHLALQ 1500 DPASDKLLGP 1510 AGLTWERNLP 1520 GAGVGKEMAG 1530 VPPTLREDER 1540 PEGPGAAWPG 1550 LEGQAYSQLE 1560 RSRQELASGL 1570 PSPAATQELP 1580 VERAAAFQVA 1590 PHSHGEEAVA 1600 QDRIPSGKQH 1610 QETSACDSPH 1620 GEDGPGDFAH 1630 TGVPGHVPRS 1640 TCAPSPQREV 1650 LTVPEANSEP 1660 WTLDTLGGER 1670 RPGVTAGILE 1680 MRNALGNQST 1690 PAPPTGEVAD 1700 TPLEPGKVAG 1710 AAGEAEGDIT 1720 LSTAETQACA 1730 SGDLPEAGTT 1740 RTFSVVAGDL 1750 VLPGSCQDPA 1760 CSDKAPGMEG 1770 TAALHGDSPA 1780 RPQQAKEQPG 1790 PERPIPAGDG 1800 KVCVSSPPEP 1810 DETHDPKLQH 1820 LAPEELHTDR 1830 ESPRPGPSML 1840 PSVPKKDAPR 1850 VMDKVTSDET 1860 RGAEGTESSP 1870 VADDIIQPAA 1880 PADLESPTLA 1890 ASSYHGDVVG 1900 QVSTDLIAQS 1910 ISPAAAHAGL 1920 PPSAAEHIVS 1930 PSAPAGDRVE 1940 ASTPSCPDPA 1950 KDLSRSSDSE 1960 EAFETPESTT 1970 PVKAPPAPPP 1980 PPPEVIPEPE 1990 VSTQPPPEEP 2000 GCGSETVPVP 2010 DGPRSDSVEG 2020 SPFRPPSHSF 2030 SAVFDEDKPI 2040 ASSGTYNLDF 2050 DNIELVDTFQ 2060 TLEPRASDAK 2070 NQEGKVNTRR 2080 KSTDSVPISK 2090 STLSRSLSLQ 2100 ASDFDGASSS 2110 GNPEAVALAP 2120 DAYSTGSSSA 2130 SSTLKRTKKP 2140 RPPSLKKKQT 2150 TKKPTETPPV 2160 KETQQEPDEE 2170 SLVPSGENLA 2180 SETKTESAKT 2190 EGPSPALLEE 2200 TPLEPAVGPK 2210 AACPLDSESA 2220 EGVVPPASGG 2230 GRVQNSPPVG 2240 RKTLPLTTAP 2250 EAGEVTPSDS 2260 GGQEDSPAKG 2270 LSVRLEFDYS 2280 EDKSSWDNQQ 2290 ENPPPTKKIG 2300 KKPVAKMPLR 2310 RPKMKKTPEK 2320 LDNTPASPPR 2330 SPAEPNDIPI 2340 AKGTYTFDID 2350 KWDDPNFNPF 2360 SSTSKMQESP 2370 KLPQQSYNFD 2380 PDTCDESVDP 2390 FKTSSKTPSS 2400 PSKSPASFEI 2410 PASAMEANGV 2420 DGDGLNKPAK 2430 KKKTPLKTDT 2440 FRVKKSPKRS 2450 PLSDPPSQDP 2460 TPAATPETPP 2470 VISAVVHATD 2480 EEKLAVTNQK 2490 WTCMTVDLEA 2500 DKQDYPQPSD 2510 LSTFVNETKF 2520 SSPTEELDYR 2530 NSYEIEYMEK 2540 IGSSLPQDDD 2550 APKKQALYLM 2560 FDTSQESPVK 2570 SSPVRMSESP 2580 TPCSGSSFEE 2590 TEALVNTAAK 2600 NQHPVPRGLA 2610 PNQESHLQVP 2620 EKSSQKELEA 2630 MGLGTPSEAI 2640 EITAPEGSFA 2650 SADALLSRLA 2660 HPVSLCGALD 2670 YLEPDLAEKN 2680 PPLFAQKLQE 2690 ELEFAIMRIE 2700 ALKLARQIAL 2710 ASRSHQDAKR 2720 EAAHPTDVSI 2730 SKTALYSRIG 2740 TAEVEKPAGL 2750 LFQQPDLDSA 2760 LQIARAEIIT 2770 KEREVSEWKD 2780 KYEESRREVM 2790 EMRKIVAEYE 2800 KTIAQMIEDE 2810 QREKSVSHQT 2820 VQQLVLEKEQ 2830 ALADLNSVEK 2840 SLADLFRRYE 2850 KMKEVLEGFR 2860 KNEEVLKRCA 2870 QEYLSRVKKE 2880 EQRYQALKVH 2890 AEEKLDRANA 2900 EIAQVRGKAQ 2910 QEQAAHQASL 2920 RKEQLRVDAL 2930 ERTLEQKNKE 2940 IEELTKICDE LIAKMGKS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0016922 nuclear receptor binding
Biological Process GO:0030953 astral microtubule organization
Biological Process GO:0021987 cerebral cortex development
Biological Process GO:0007052 mitotic spindle organization
Biological Process GO:0007097 nuclear migration

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.