Overview
| Uniprot ID | O95372 |
|---|
| Protein Name | Acyl-protein thioesterase 2 |
|---|
| Gene Name | LYPLA2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 190 |
FGALTAEKLRSVVTP |
Function
Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GSDMD, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (PubMed:25301951). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951)
Protein Sequence
10
MCGNTMSVPL
20
LTDAATVSGA
30
ERETAAVIFL
40
HGLGDTGHSW
50
ADALSTIRLP
60
HVKYICPHAP
70
RIPVTLNMKM
80
VMPSWFDLMG
90
LSPDAPEDEA
100
GIKKAAENIK
110
ALIEHEMKNG
120
IPANRIVLGG
130
FSQGGALSLY
140
TALTCPHPLA
150
GIVALSCWLP
160
LHRAFPQAAN
170
GSAKDLAILQ
180
CHGELDPMVP
190
VRFGALTAEK
200
LRSVVTPARV
210
QFKTYPGVMH
220
SSCPQEMAAV
230
KEFLEKLLPP
V
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005795 |
Golgi stack |
| Molecular Function |
GO:0045296 |
cadherin binding |
| Molecular Function |
GO:0008474 |
palmitoyl-(protein) hydrolase activity |
| Molecular Function |
GO:0004622 |
phosphatidylcholine lysophospholipase A1 activity |
| Biological Process |
GO:0046464 |
acylglycerol catabolic process |
| Biological Process |
GO:0007411 |
axon guidance |
| Biological Process |
GO:0006631 |
fatty acid metabolic process |
| Biological Process |
GO:1905344 |
prostaglandin catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.