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Overview

Uniprot IDO95382
Protein NameMitogen-activated protein kinase kinase kinase 6
Gene NameMAP3K6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1024 ENLHQEQKQEQGARL

Function

Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways

Protein Sequence

10 MAGPCPRSGA 20 ERAGSCWQDP 30 LAVALSRGRQ 40 LAAPPGRGCA 50 RSRPLSVVYV 60 LTREPQPGLE 70 PREGTEAEPL 80 PLRCLREACA 90 QVPRPRPPPQ 100 LRSLPFGTLE 110 LGDTAALDAF 120 YNADVVVLEV 130 SSSLVQPSLF 140 YHLGVRESFS 150 MTNNVLLCSQ 160 ADLPDLQALR 170 EDVFQKNSDC 180 VGSYTLIPYV 190 VTATGRVLCG 200 DAGLLRGLAD 210 GLVQAGVGTE 220 ALLTPLVGRL 230 ARLLEATPTD 240 SCGYFRETIR 250 RDIRQARERF 260 SGPQLRQELA 270 RLQRRLDSVE 280 LLSPDIIMNL 290 LLSYRDVQDY 300 SAIIELVETL 310 QALPTCDVAE 320 QHNVCFHYTF 330 ALNRRNRPGD 340 RAKALSVLLP 350 LVQLEGSVAP 360 DLYCMCGRIY 370 KDMFFSSGFQ 380 DAGHREQAYH 390 WYRKAFDVEP 400 SLHSGINAAV 410 LLIAAGQHFE 420 DSKELRLIGM 430 KLGCLLARKG 440 CVEKMQYYWD 450 VGFYLGAQIL 460 ANDPTQVVLA 470 AEQLYKLNAP 480 IWYLVSVMET 490 FLLYQHFRPT 500 PEPPGGPPRR 510 AHFWLHFLLQ 520 SCQPFKTACA 530 QGDQCLVLVL 540 EMNKVLLPAK 550 LEVRGTDPVS 560 TVTLSLLEPE 570 TQDIPSSWTF 580 PVASICGVSA 590 SKRDERCCFL 600 YALPPAQDVQ 610 LCFPSVGHCQ 620 WFCGLIQAWV 630 TNPDSTAPAE 640 EAEGAGEMLE 650 FDYEYTETGE 660 RLVLGKGTYG 670 VVYAGRDRHT 680 RVRIAIKEIP 690 ERDSRFSQPL 700 HEEIALHRRL 710 RHKNIVRYLG 720 SASQGGYLKI 730 FMEEVPGGSL 740 SSLLRSVWGP 750 LKDNESTISF 760 YTRQILQGLG 770 YLHDNHIVHR 780 DIKGDNVLIN 790 TFSGLLKISD 800 FGTSKRLAGI 810 TPCTETFTGT 820 LQYMAPEIID 830 QGPRGYGKAA 840 DIWSLGCTVI 850 EMATGRPPFH 860 ELGSPQAAMF 870 QVGMYKVHPP 880 MPSSLSAEAQ 890 AFLLRTFEPD 900 PRLRASAQTL 910 LGDPFLQPGK 920 RSRSPSSPRH 930 APRPSDAPSA 940 SPTPSANSTT 950 QSQTFPCPQA 960 PSQHPPSPPK 970 RCLSYGGTSQ 980 LRVPEEPAAE 990 EPASPEESSG 1000 LSLLHQESKR 1010 RAMLAAVLEQ 1020 ELPALAENLH 1030 QEQKQEQGAR 1040 LGRNHVEELL 1050 RCLGAHIHTP 1060 NRRQLAQELR 1070 ALQGRLRAQG 1080 LGPALLHRPL 1090 FAFPDAVKQI 1100 LRKRQIRPHW 1110 MFVLDSLLSR 1120 AVRAALGVLG 1130 PEVEKEAVSP 1140 RSEELSNEGD 1150 SQQSPGQQSP 1160 LPVEPEQGPA 1170 PLMVQLSLLR 1180 AETDRLREIL 1190 AGKEREYQAL 1200 VQRALQRLNE 1210 EARTYVLAPE 1220 PPTALSTDQG 1230 LVQWLQELNV 1240 DSGTIQMLLN 1250 HSFTLHTLLT 1260 YATRDDLIYT 1270 RIRGGMVCRI 1280 WRAILAQRAG STPVTSGP

Gene Ontology

Classification GO ID Description
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0004709 MAP kinase kinase kinase activity
Molecular Function GO:0106310 protein serine kinase activity
Biological Process GO:0007254 JNK cascade
Biological Process GO:0038066 p38MAPK cascade
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0007165 signal transduction

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.