Search Results

Overview

Uniprot IDO95391
Protein NamePre-mRNA-splicing factor SLU7
Gene NameSLU7
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
114 KENSIITKYRKGACE
117 SIITKYRKGACENCG
199 KRTLKAQKLQEELAS
355 TKLELLYKSFKVKKE
527 KKHEKLKKALNAEEA

Function

Required for pre-mRNA splicing as component of the spliceosome (PubMed:10197984, PubMed:28502770, PubMed:30705154). Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation

Protein Sequence

10 MSATVVDAVN 20 AAPLSGSKEM 30 SLEEPKKMTR 40 EDWRKKKELE 50 EQRKLGNAPA 60 EVDEEGKDIN 70 PHIPQYISSV 80 PWYIDPSKRP 90 TLKHQRPQPE 100 KQKQFSSSGE 110 WYKRGVKENS 120 IITKYRKGAC 130 ENCGAMTHKK 140 KDCFERPRRV 150 GAKFTGTNIA 160 PDEHVQPQLM 170 FDYDGKRDRW 180 NGYNPEEHMK 190 IVEEYAKVDL 200 AKRTLKAQKL 210 QEELASGKLV 220 EQANSPKHQW 230 GEEEPNSQME 240 KDHNSEDEDE 250 DKYADDIDMP 260 GQNFDSKRRI 270 TVRNLRIRED 280 IAKYLRNLDP 290 NSAYYDPKTR 300 AMRENPYANA 310 GKNPDEVSYA 320 GDNFVRYTGD 330 TISMAQTQLF 340 AWEAYDKGSE 350 VHLQADPTKL 360 ELLYKSFKVK 370 KEDFKEQQKE 380 SILEKYGGQE 390 HLDAPPAELL 400 LAQTEDYVEY 410 SRHGTVIKGQ 420 ERAVACSKYE 430 EDVKIHNHTH 440 IWGSYWKEGR 450 WGYKCCHSFF 460 KYSYCTGEAG 470 KEIVNSEECI 480 INEITGEESV 490 KKPQTLMELH 500 QEKLKEEKKK 510 KKKKKKKHRK 520 SSSDSDDEEK 530 KHEKLKKALN 540 AEEARLLHVK 550 ETMQIDERKR 560 PYNSMYETRE 570 PTEEEMEAYR 580 MKRQRPDDPM ASFLGQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016020 membrane
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0030532 small nuclear ribonucleoprotein complex
Cellular Component GO:0005681 spliceosomal complex
Molecular Function GO:0030628 pre-mRNA 3'-splice site binding
Molecular Function GO:0000386 second spliceosomal transesterification activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0000380 alternative mRNA splicing, via spliceosome
Biological Process GO:0034605 cellular response to heat
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0000389 mRNA 3'-splice site recognition
Biological Process GO:0045292 mRNA cis splicing, via spliceosome
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0000375 RNA splicing, via transesterification reactions

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.