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Overview

Uniprot IDO95394
Protein NamePhosphoacetylglucosamine mutase
Gene NamePGM3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
350 KVPVYCTKTGVKHLH
453 DLPNRQLKVQVADRR

Function

Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation

Protein Sequence

10 MDLGAITKYS 20 ALHAKPNGLI 30 LQYGTAGFRT 40 KAEHLDHVMF 50 RMGLLAVLRS 60 KQTKSTIGVM 70 VTASHNPEED 80 NGVKLVDPLG 90 EMLAPSWEEH 100 ATCLANAEEQ 110 DMQRVLIDIS 120 EKEAVNLQQD 130 AFVVIGRDTR 140 PSSEKLSQSV 150 IDGVTVLGGQ 160 FHDYGLLTTP 170 QLHYMVYCRN 180 TGGRYGKATI 190 EGYYQKLSKA 200 FVELTKQASC 210 SGDEYRSLKV 220 DCANGIGALK 230 LREMEHYFSQ 240 GLSVQLFNDG 250 SKGKLNHLCG 260 ADFVKSHQKP 270 PQGMEIKSNE 280 RCCSFDGDAD 290 RIVYYYHDAD 300 GHFHLIDGDK 310 IATLISSFLK 320 ELLVEIGESL 330 NIGVVQTAYA 340 NGSSTRYLEE 350 VMKVPVYCTK 360 TGVKHLHHKA 370 QEFDIGVYFE 380 ANGHGTALFS 390 TAVEMKIKQS 400 AEQLEDKKRK 410 AAKMLENIID 420 LFNQAAGDAI 430 SDMLVIEAIL 440 ALKGLTVQQW 450 DALYTDLPNR 460 QLKVQVADRR 470 VISTTDAERQ 480 AVTPPGLQEA 490 INDLVKKYKL 500 SRAFVRPSGT 510 EDVVRVYAEA 520 DSQESADHLA 530 HEVSLAVFQL 540 AGGIGERPQP GF

Gene Ontology

Classification GO ID Description
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0004610 phosphoacetylglucosamine mutase activity
Biological Process GO:0005975 carbohydrate metabolic process
Biological Process GO:0006041 glucosamine metabolic process
Biological Process GO:0030097 hemopoiesis
Biological Process GO:0006487 protein N-linked glycosylation
Biological Process GO:0006493 protein O-linked glycosylation
Biological Process GO:0006048 UDP-N-acetylglucosamine biosynthetic process
Cellular Component GO:0005829 cytosol

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.