Search Results

Overview

Uniprot IDO95400
Protein NameCD2 antigen cytoplasmic tail-binding protein 2
Gene NameCD2BP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
188 RGGGKGRKGPGQPSS
24 EDEIIVPKKKLVDPV
25 DEIIVPKKKLVDPVA
26 EIIVPKKKLVDPVAG
321 PDGVYCRKLDPPGGQ
5 ***MPKRKVTFQGVG

Function

Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly

Protein Sequence

10 MPKRKVTFQG 20 VGDEEDEDEI 30 IVPKKKLVDP 40 VAGSGGPGSR 50 FKGKHSLDSD 60 EEEDDDDGGS 70 SKYDILASED 80 VEGQEAATLP 90 SEGGVRITPF 100 NLQEEMEEGH 110 FDADGNYFLN 120 RDAQIRDSWL 130 DNIDWVKIRE 140 RPPGQRQASD 150 SEEEDSLGQT 160 SMSAQALLEG 170 LLELLLPRET 180 VAGALRRLGA 190 RGGGKGRKGP 200 GQPSSPQRLD 210 RLSGLADQMV 220 ARGNLGVYQE 230 TRERLAMRLK 240 GLGCQTLGPH 250 NPTPPPSLDM 260 FAEELAEEEL 270 ETPTPTQRGE 280 AESRGDGLVD 290 VMWEYKWENT 300 GDAELYGPFT 310 SAQMQTWVSE 320 GYFPDGVYCR 330 KLDPPGGQFY 340 NSKRIDFDLY T

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005682 U5 snRNP
Molecular Function GO:0043021 ribonucleoprotein complex binding
Biological Process GO:0000398 mRNA splicing, via spliceosome
Biological Process GO:0000244 spliceosomal tri-snRNP complex assembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.