Search Results

Overview

Uniprot IDO95425
Protein NameSupervillin
Gene NameSVIL
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
697 AKLSVAAKRLLFREM
992 GDSHKESKYAVPRRG

Function

Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation (PubMed:12711699). Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (PubMed:19109420). In addition to its cytoskeletal activities, acts as a cofactor or scaffold for KDM1A, facilitating H3K9me2 demethylation and promoting gene activation, especially in neuronal contexts (PubMed:25684206)

Protein Sequence

10 MKRKERIARR 20 LEGIENDTQP 30 ILLQSCTGLV 40 THRLLEEDTP 50 RYMRASDPAS 60 PHIGRSNEEE 70 ETSDSSLEKQ 80 TRSKYCTETS 90 GVHGDSPYGS 100 GTMDTHSLES 110 KAERIARYKA 120 ERRRQLAEKY 130 GLTLDPEADS 140 EYLSRYTKSR 150 KEPDAVEKRG 160 GKSDKQEESS 170 RDASSLYPGT 180 ETMGLRTCAG 190 ESKDYALHVG 200 DGSSDPEVLL 210 NIENQRRGQE 220 LSATRQAHDL 230 SPAAESSSTF 240 SFSGRDSSFT 250 EVPRSPKHAH 260 SSSLQQAASR 270 SPSFGDPQLS 280 PEARPSTGKP 290 KHEWFLQKDS 300 EGDTPSLINW 310 PSRVKVREKL 320 VKEESARNSP 330 ELASESVTQR 340 RHQPAPVHYV 350 SFQSEHSAFD 360 RVPSKAAGST 370 RQPIRGYVQP 380 ADTGHTAKLV 390 TPETPENASE 400 CSWVASATQN 410 VPKPPSLTVL 420 EGDGRDSPVL 430 HVCESKAEEE 440 EGEGEGEEKE 450 EDVCFTEALE 460 QSKKTLLALE 470 GDGLVRSPED 480 PSRNEDFGKP 490 AVSTVTLEHQ 500 KELENVAQPP 510 QAPHQPTERT 520 GRSEMVLYIQ 530 SEPVSQDAKP 540 TGHNREASKK 550 RKVRTRSLSD 560 FTGPPQLQAL 570 KYKDPASRRE 580 LELPSSKTEG 590 PYGEISMLDT 600 KVSVAQLRSA 610 FLASANACRR 620 PELKSRVERS 630 AEGPGLPTGV 640 ERERGSRKPR 650 RYFSPGESRK 660 TSERFRTQPI 670 TSAERKESDR 680 CTSHSETPTV 690 DDEEKVDERA 700 KLSVAAKRLL 710 FREMEKSFDE 720 QNVPKRRSRN 730 TAVEQRLRRL 740 QDRSLTQPIT 750 TEEVVIAATE 760 PIPASCSGGT 770 HPVMARLPSP 780 TVARSAVQPA 790 RLQASAHQKA 800 LAKDQTNEGK 810 ELAEQGEPDS 820 STLSLAEKLA 830 LFNKLSQPVS 840 KAISTRNRID 850 TRQRRMNARY 860 QTQPVTLGEV 870 EQVQSGKLIP 880 FSPAVNTSVS 890 TVASTVAPMY 900 AGDLRTKPPL 910 DHNASATDYK 920 FSSSIENSDS 930 PVRSILKSQA 940 WQPLVEGSEN 950 KGMLREYGET 960 ESKRALTGRD 970 SGMEKYGSFE 980 EAEASYPILN 990 RAREGDSHKE 1000 SKYAVPRRGS 1010 LERANPPITH 1020 LGDEPKEFSM 1030 AKMNAQGNLD 1040 LRDRLPFEEK 1050 VEVENVMKRK 1060 FSLRAAEFGE 1070 PTSEQTGTAA 1080 GKTIAQTTAP 1090 VSWKPQDSSE 1100 QPQEKLCKNP 1110 CAMFAAGEIK 1120 TPTGEGLLDS 1130 PSKTMSIKER 1140 LALLKKSGEE 1150 DWRNRLSRRQ 1160 EGGKAPASSL 1170 HTQEAGRSLI 1180 KKRVTESRES 1190 QMTIEERKQL 1200 ITVREEAWKT 1210 RGRGAANDST 1220 QFTVAGRMVK 1230 KGLASPTAIT 1240 PVASPICGKT 1250 RGTTPVSKPL 1260 EDIEARPDMQ 1270 LESDLKLDRL 1280 ETFLRRLNNK 1290 VGGMHETVLT 1300 VTGKSVKEVM 1310 KPDDDETFAK 1320 FYRSVDYNMP 1330 RSPVEMDEDF 1340 DVIFDPYAPK 1350 LTSSVAEHKR 1360 AVRPKRRVQA 1370 SKNPLKMLAA 1380 REDLLQEYTE 1390 QRLNVAFMES 1400 KRMKVEKMSS 1410 NSNFSEVTLA 1420 GLASKENFSN 1430 VSLRSVNLTE 1440 QNSNNSAVPY 1450 KRLMLLQIKG 1460 RRHVQTRLVE 1470 PRASALNSGD 1480 CFLLLSPHCC 1490 FLWVGEFANV 1500 IEKAKASELA 1510 TLIQTKRELG 1520 CRATYIQTIE 1530 EGINTHTHAA 1540 KDFWKLLGGQ 1550 TSYQSAGDPK 1560 EDELYEAAII 1570 ETNCIYRLMD 1580 DKLVPDDDYW 1590 GKIPKCSLLQ 1600 PKEVLVFDFG 1610 SEVYVWHGKE 1620 VTLAQRKIAF 1630 QLAKHLWNGT 1640 FDYENCDINP 1650 LDPGECNPLI 1660 PRKGQGRPDW 1670 AIFGRLTEHN 1680 ETILFKEKFL 1690 DWTELKRSNE 1700 KNPGELAQHK 1710 EDPRTDVKAY 1720 DVTRMVSMPQ 1730 TTAGTILDGV 1740 NVGRGYGLVE 1750 GHDRRQFEIT 1760 SVSVDVWHIL 1770 EFDYSRLPKQ 1780 SIGQFHEGDA 1790 YVVKWKFMVS 1800 TAVGSRQKGE 1810 HSVRAAGKEK 1820 CVYFFWQGRH 1830 STVSEKGTSA 1840 LMTVELDEER 1850 GAQVQVLQGK 1860 EPPCFLQCFQ 1870 GGMVVHSGRR 1880 EEEEENVQSE 1890 WRLYCVRGEV 1900 PVEGNLLEVA 1910 CHCSSLRSRT 1920 SMVVLNVNKA 1930 LIYLWHGCKA 1940 QAHTKEVGRT 1950 AANKIKEQCP 1960 LEAGLHSSSK 1970 VTIHECDEGS 1980 EPLGFWDALG 1990 RRDRKAYDCM 2000 LQDPGSFNFA 2010 PRLFILSSSS 2020 GDFAATEFVY 2030 PARAPSVVSS 2040 MPFLQEDLYS 2050 APQPALFLVD 2060 NHHEVYLWQG 2070 WWPIENKITG 2080 SARIRWASDR 2090 KSAMETVLQY 2100 CKGKNLKKPA 2110 PKSYLIHAGL 2120 EPLTFTNMFP 2130 SWEHREDIAE 2140 ITEMDTEVSN 2150 QITLVEDVLA 2160 KLCKTIYPLA 2170 DLLARPLPEG 2180 VDPLKLEIYL 2190 TDEDFEFALD 2200 MTRDEYNALP 2210 AWKQVNLKKA KGLF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0042995 cell projection
Cellular Component GO:0032154 cleavage furrow
Cellular Component GO:0043034 costamere
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0036449 microtubule minus-end
Cellular Component GO:0030496 midbody
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0002102 podosome
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Biological Process GO:0051014 actin filament severing
Biological Process GO:0008154 actin polymerization or depolymerization
Biological Process GO:0051016 barbed-end actin filament capping
Biological Process GO:0032467 positive regulation of cytokinesis
Biological Process GO:0007519 skeletal muscle tissue development

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.