Search Results
Overview
| Uniprot ID | O95456 |
|---|---|
| Protein Name | Proteasome assembly chaperone 1 |
| Gene Name | PSMG1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 55 | RLLRRQTKTSLEVSL |
Function
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization
Protein Sequence
10
MAATFFGEVV
20
KAPCRAGTED
30
EEEEEEGRRE
40
TPEDREVRLQ
50
LARKREVRLL
60
RRQTKTSLEV
70
SLLEKYPCSK
80
FIIAIGNNAV
90
AFLSSFVMNS
100
GVWEEVGCAK
110
LWNEWCRTTD
120
TTHLSSTEAF
130
CVFYHLKSNP
140
SVFLCQCSCY
150
VAEDQQYQWL
160
EKVFGSCPRK
170
NMQITILTCR
180
HVTDYKTSES
190
TGSLPSPFLR
200
ALKTQNFKDS
210
ACCPLLEQPN
220
IVHDLPAAVL
230
SYCQVWKIPA
240
ILYLCYTDVM
250
KLDLITVEAF
260
KPILSTRSLK
270
GLVKNIPQST
280
EILKKLMTTN
EIQSNIYT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0101031 | protein folding chaperone complex |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0070628 | proteasome binding |
| Biological Process | GO:0051131 | chaperone-mediated protein complex assembly |
| Biological Process | GO:0080129 | proteasome core complex assembly |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.