Overview
| Uniprot ID | O95470 |
|---|
| Protein Name | Sphingosine-1-phosphate lyase 1 |
|---|
| Gene Name | SGPL1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 353 |
SISADTHKYGYAPKG |
Function
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (PubMed:11018465, PubMed:14570870, PubMed:24809814, PubMed:28165339). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity)
Protein Sequence
10
MPSTDLLMLK
20
AFEPYLEILE
30
VYSTKAKNYV
40
NGHCTKYEPW
50
QLIAWSVVWT
60
LLIVWGYEFV
70
FQPESLWSRF
80
KKKCFKLTRK
90
MPIIGRKIQD
100
KLNKTKDDIS
110
KNMSFLKVDK
120
EYVKALPSQG
130
LSSSAVLEKL
140
KEYSSMDAFW
150
QEGRASGTVY
160
SGEEKLTELL
170
VKAYGDFAWS
180
NPLHPDIFPG
190
LRKIEAEIVR
200
IACSLFNGGP
210
DSCGCVTSGG
220
TESILMACKA
230
YRDLAFEKGI
240
KTPEIVAPQS
250
AHAAFNKAAS
260
YFGMKIVRVP
270
LTKMMEVDVR
280
AMRRAISRNT
290
AMLVCSTPQF
300
PHGVIDPVPE
310
VAKLAVKYKI
320
PLHVDACLGG
330
FLIVFMEKAG
340
YPLEHPFDFR
350
VKGVTSISAD
360
THKYGYAPKG
370
SSLVLYSDKK
380
YRNYQFFVDT
390
DWQGGIYASP
400
TIAGSRPGGI
410
SAACWAALMH
420
FGENGYVEAT
430
KQIIKTARFL
440
KSELENIKGI
450
FVFGNPQLSV
460
IALGSRDFDI
470
YRLSNLMTAK
480
GWNLNQLQFP
490
PSIHFCITLL
500
HARKRVAIQF
510
LKDIRESVTQ
520
IMKNPKAKTT
530
GMGAIYGMAQ
540
TTVDRNMVAE
550
LSSVFLDSLY
560
STDTVTQGSQ
MNGSPKPH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Molecular Function |
GO:0030170 |
pyridoxal phosphate binding |
| Molecular Function |
GO:0008117 |
sphinganine-1-phosphate aldolase activity |
| Biological Process |
GO:0097190 |
apoptotic signaling pathway |
| Biological Process |
GO:0006672 |
ceramide metabolic process |
| Biological Process |
GO:0006631 |
fatty acid metabolic process |
| Biological Process |
GO:0030149 |
sphingolipid catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.