Search Results

Overview

Uniprot IDO95487
Protein NameProtein transport protein Sec24B
Gene NameSEC24B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
836 PNQRSSTKVVQHLGP

Function

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24A may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296)

Protein Sequence

10 MSAPAGSSHP 20 AASARIPPKF 30 GGAAVSGAAA 40 PAGPGAGPAP 50 HQQNGPAQNQ 60 MQVPSGYGLH 70 HQNYIAPSGH 80 YSQGPGKMTS 90 LPLDTQCGDY 100 YSALYTVPTQ 110 NVTPNTVNQQ 120 PGAQQLYSRG 130 PPAPHIVGST 140 LGSFQGAASS 150 ASHLHTSASQ 160 PYSSFVNHYN 170 SPAMYSASSS 180 VASQGFPSTC 190 GHYAMSTVSN 200 AAYPSVSYPS 210 LPAGDTYGQM 220 FTSQNAPTVR 230 PVKDNSFSGQ 240 NTAISHPSPL 250 PPLPSQQHHQ 260 QQSLSGYSTL 270 TWSSPGLPST 280 QDNLIRNHTG 290 SLAVANNNPT 300 ITVADSLSCP 310 VMQNVQPPKS 320 SPVVSTVLSG 330 SSGSSSTRTP 340 PTANHPVEPV 350 TSVTQPSELL 360 QQKGVQYGEY 370 VNNQASSAPT 380 PLSSTSDDEE 390 EEEEDEEAGV 400 DSSSTTSSAS 410 PMPNSYDALE 420 GGSYPDMLSS 430 SASSPAPDPA 440 PEPDPASAPA 450 PASAPAPVVP 460 QPSKMAKPFG 470 YGYPTLQPGY 480 QNATAPLISG 490 VQPSNPVYSG 500 FQQYPQQYPG 510 VNQLSSSIGG 520 LSLQSSPQPE 530 SLRPVNLTQE 540 RNILPMTPVW 550 APVPNLNADL 560 KKLNCSPDSF 570 RCTLTNIPQT 580 QALLNKAKLP 590 LGLLLHPFRD 600 LTQLPVITSN 610 TIVRCRSCRT 620 YINPFVSFID 630 QRRWKCNLCY 640 RVNDVPEEFM 650 YNPLTRSYGE 660 PHKRPEVQNS 670 TVEFIASSDY 680 MLRPPQPAVY 690 LFVLDVSHNA 700 VEAGYLTILC 710 QSLLENLDKL 720 PGDSRTRIGF 730 MTFDSTIHFY 740 NLQEGLSQPQ 750 MLIVSDIDDV 760 FLPTPDSLLV 770 NLYESKELIK 780 DLLNALPNMF 790 TNTRETHSAL 800 GPALQAAFKL 810 MSPTGGRVSV 820 FQTQLPSLGA 830 GLLQSREDPN 840 QRSSTKVVQH 850 LGPATDFYKK 860 LALDCSGQQT 870 AVDLFLLSSQ 880 YSDLASLACM 890 SKYSAGCIYY 900 YPSFHYTHNP 910 SQAEKLQKDL 920 KRYLTRKIGF 930 EAVMRIRCTK 940 GLSMHTFHGN 950 FFVRSTDLLS 960 LANINPDAGF 970 AVQLSIEESL 980 TDTSLVCFQT 990 ALLYTSSKGE 1000 RRIRVHTLCL 1010 PVVSSLADVY 1020 AGVDVQAAIC 1030 LLANMAVDRS 1040 VSSSLSDARD 1050 ALVNAVVDSL 1060 SAYGSTVSNL 1070 QHSALMAPSS 1080 LKLFPLYVLA 1090 LLKQKAFRTG 1100 TSTRLDDRVY 1110 AMCQIKSQPL 1120 VHLMKMIHPN 1130 LYRIDRLTDE 1140 GAVHVNDRIV 1150 PQPPLQKLSA 1160 EKLTREGAFL 1170 MDCGSVFYIW 1180 VGKGCDNNFI 1190 EDVLGYTNFA 1200 SIPQKMTHLP 1210 ELDTLSSERA 1220 RSFITWLRDS 1230 RPLSPILHIV 1240 KDESPAKAEF 1250 FQHLIEDRTE 1260 AAFSYYEFLL HVQQQICK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030127 COPII vesicle coat
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0070971 endoplasmic reticulum exit site
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0012507 ER to Golgi transport vesicle membrane
Molecular Function GO:0000149 SNARE binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0090110 COPII-coated vesicle cargo loading
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport
Biological Process GO:0070863 positive regulation of protein exit from endoplasmic reticulum

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.