Search Results
Overview
| Uniprot ID | O95497 |
|---|---|
| Protein Name | Pantetheinase |
| Gene Name | VNN1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 272 | SNIHYPSKKMTGSGI |
Function
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine
Protein Sequence
10
MTTQLPAYVA
20
ILLFYVSRAS
30
CQDTFTAAVY
40
EHAAILPNAT
50
LTPVSREEAL
60
ALMNRNLDIL
70
EGAITSAADQ
80
GAHIIVTPED
90
AIYGWNFNRD
100
SLYPYLEDIP
110
DPEVNWIPCN
120
NRNRFGQTPV
130
QERLSCLAKN
140
NSIYVVANIG
150
DKKPCDTSDP
160
QCPPDGRYQY
170
NTDVVFDSQG
180
KLVARYHKQN
190
LFMGENQFNV
200
PKEPEIVTFN
210
TTFGSFGIFT
220
CFDILFHDPA
230
VTLVKDFHVD
240
TIVFPTAWMN
250
VLPHLSAVEF
260
HSAWAMGMRV
270
NFLASNIHYP
280
SKKMTGSGIY
290
APNSSRAFHY
300
DMKTEEGKLL
310
LSQLDSHPSH
320
SAVVNWTSYA
330
SSIEALSSGN
340
KEFKGTVFFD
350
EFTFVKLTGV
360
AGNYTVCQKD
370
LCCHLSYKMS
380
ENIPNEVYAL
390
GAFDGLHTVE
400
GRYYLQICTL
410
LKCKTTNLNT
420
CGDSAETAST
430
RFEMFSLSGT
440
FGTQYVFPEV
450
LLSENQLAPG
460
EFQVSTDGRL
470
FSLKPTSGPV
480
LTVTLFGRLY
490
EKDWASNASS
500
GLTAQARIIM
510
LIVIAPIVCS
LSW
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035577 | azurophil granule membrane |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098552 | side of membrane |
| Molecular Function | GO:0017159 | pantetheine hydrolase activity |
| Biological Process | GO:0002526 | acute inflammatory response |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0002544 | chronic inflammatory response |
| Biological Process | GO:0015938 | coenzyme A catabolic process |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0015939 | pantothenate metabolic process |
| Biological Process | GO:1902177 | positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| Biological Process | GO:0033089 | positive regulation of T cell differentiation in thymus |
| Biological Process | GO:0006979 | response to oxidative stress |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.