Overview
| Uniprot ID | O95503 |
|---|
| Protein Name | Chromobox protein homolog 6 |
|---|
| Gene Name | CBX6 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 60 |
LIAAFEQKERERELY |
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity)
Protein Sequence
10
MELSAVGERV
20
FAAESIIKRR
30
IRKGRIEYLV
40
KWKGWAIKYS
50
TWEPEENILD
60
SRLIAAFEQK
70
ERERELYGPK
80
KRGPKPKTFL
90
LKARAQAEAL
100
RISDVHFSVK
110
PSASASSPKL
120
HSSAAVHRLK
130
KDIRRCHRMS
140
RRPLPRPDPQ
150
GGSPGLRPPI
160
SPFSETVRII
170
NRKVKPREPK
180
RNRIILNLKV
190
IDKGAGGGGA
200
GQGAGALARP
210
KVPSRNRVIG
220
KSKKFSESVL
230
RTQIRHMKFG
240
AFALYKPPPA
250
PLVAPSPGKA
260
EASAPGPGLL
270
LAAPAAPYDA
280
RSSGSSGCPS
290
PTPQSSDPDD
300
TPPKLLPETV
310
SPSAPSWREP
320
EVLDLSLPPE
330
SAATSKRAPP
340
EVTAAAGPAP
350
PTAPEPAGAS
360
SEPEAGDWRP
370
EMSPCSNVVV
380
TDVTSNLLTV
390
TIKEFCNPED
400
FEKVAAGVAG
410
AAGGGGSIGA
SK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0000792 |
heterochromatin |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0031519 |
PcG protein complex |
| Cellular Component |
GO:0035102 |
PRC1 complex |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0003727 |
single-stranded RNA binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0031507 |
heterochromatin formation |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.