Search Results
Overview
| Uniprot ID | O95563 |
|---|---|
| Protein Name | Mitochondrial pyruvate carrier 2 |
| Gene Name | MPC2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 122 | WRYNQELKAKAHK** |
Function
Mediates the uptake of pyruvate into mitochondria to maintain the balance between glycolysis and oxidative phosphorylation (PubMed:22628558, PubMed:26253029, PubMed:27317664, PubMed:29472561, PubMed:40044865, PubMed:40101766, PubMed:35278701). Plays an essential role in cellular metabolism (PubMed:40044865, PubMed:40101766)
Protein Sequence
10
MSAAGARGLR
20
ATYHRLLDKV
30
ELMLPEKLRP
40
LYNHPAGPRT
50
VFFWAPIMKW
60
GLVCAGLADM
70
ARPAEKLSTA
80
QSAVLMATGF
90
IWSRYSLVII
100
PKNWSLFAVN
110
FFVGAAGASQ
120
LFRIWRYNQE
LKAKAHK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:7770001 | mitochondrial pyruvate carrier complex |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0050833 | pyruvate transmembrane transporter activity |
| Biological Process | GO:0006850 | pyruvate import into mitochondria |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.