Search Results
Overview
| Uniprot ID | O95568 |
|---|---|
| Protein Name | Histidine protein methyltransferase 1 homolog |
| Gene Name | METTL18 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 282 | KLVLSSEKLFVKYDL |
Function
Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation (PubMed:23349634, PubMed:33693809, PubMed:35674491). Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins (PubMed:35674491)
Protein Sequence
10
MTFQFNFTIE
20
DHLENELTPI
30
RDGALTLDSS
40
KELSVSESQK
50
GEERDRKCSA
60
EQFDLPQDHL
70
WEHKSMENAA
80
PSQDTDSPLS
90
AASSSRNLEP
100
HGKQPSLRAA
110
KEHAMPKDLK
120
KMLENKVIET
130
LPGFQHVKLS
140
VVKTILLKEN
150
FPGENIVSKS
160
FSSHSDLITG
170
VYEGGLKIWE
180
CTFDLLAYFT
190
KAKVKFAGKK
200
VLDLGCGSGL
210
LGITAFKGGS
220
KEIHFQDYNS
230
MVIDEVTLPN
240
VVANSTLEDE
250
ENDVNEPDVK
260
RCRKPKVTQL
270
YKCRFFSGEW
280
SEFCKLVLSS
290
EKLFVKYDLI
300
LTSETIYNPD
310
YYSNLHQTFL
320
RLLSKNGRVL
330
LASKAHYFGV
340
GGGVHLFQKF
350
VEERDVFKTR
360
ILKIIDEGLK
370
RFIIEITFKF
PG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0031072 | heat shock protein binding |
| Molecular Function | GO:0018064 | protein-L-histidine N-tele-methyltransferase activity |
| Biological Process | GO:0018026 | peptidyl-lysine monomethylation |
| Biological Process | GO:0090069 | regulation of ribosome biogenesis |
| Biological Process | GO:2000232 | regulation of rRNA processing |
| Biological Process | GO:0006417 | regulation of translation |
| Biological Process | GO:0006448 | regulation of translational elongation |
Reference
PMID: N/A