Overview
| Uniprot ID | O95571 |
|---|
| Protein Name | Persulfide dioxygenase ETHE1, mitochondrial |
|---|
| Gene Name | ETHE1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 172 |
DFQQGCAKTLYHSVH |
| 66 |
PRDAQLIKELGLRLL |
Function
Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897)
Protein Sequence
10
MAEAVLRVAR
20
RQLSQRGGSG
30
APILLRQMFE
40
PVSCTFTYLL
50
GDRESREAVL
60
IDPVLETAPR
70
DAQLIKELGL
80
RLLYAVNTHC
90
HADHITGSGL
100
LRSLLPGCQS
110
VISRLSGAQA
120
DLHIEDGDSI
130
RFGRFALETR
140
ASPGHTPGCV
150
TFVLNDHSMA
160
FTGDALLIRG
170
CGRTDFQQGC
180
AKTLYHSVHE
190
KIFTLPGDCL
200
IYPAHDYHGF
210
TVSTVEEERT
220
LNPRLTLSCE
230
EFVKIMGNLN
240
LPKPQQIDFA
250
VPANMRCGVQ
TPTA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0005506 |
iron ion binding |
| Molecular Function |
GO:0050313 |
sulfur dioxygenase activity |
| Biological Process |
GO:0006749 |
glutathione metabolic process |
| Biological Process |
GO:0070813 |
hydrogen sulfide metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.