Search Results

Overview

Uniprot IDO95613
Protein NamePericentrin
Gene NamePCNT
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1106 NHQVQQLKDQVLSLS
1587 QLQEEVEKQKNIVKG
2052 LEDGGKGKEKVLEDC

Function

Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome

Protein Sequence

10 MEVEQEQRRR 20 KVEAGRTKLA 30 HFRQRKTKGD 40 SSHSEKKTAK 50 RKGSAVDASV 60 QEESPVTKED 70 SALCGGGDIC 80 KSTSCDDTPD 90 GAGGAFAAQP 100 EDCDGEKRED 110 LEQLQQKQVN 120 DHPPEQCGMF 130 TVSDHPPEQH 140 GMFTVGDHPP 150 EQRGMFTVSD 160 HPPEQHGMFT 170 VSDHPPEQRG 180 MFTISDHQPE 190 QRGMFTVSDH 200 TPEQRGIFTI 210 SDHPAEQRGM 220 FTKECEQECE 230 LAITDLESGR 240 EDEAGLHQSQ 250 AVHGLELEAL 260 RLSLSNMHTA 270 QLELTQANLQ 280 KEKETALTEL 290 REMLNSRRAQ 300 ELALLQSRQQ 310 HELELLREQH 320 AREKEEVVLR 330 CGQEAAELKE 340 KLQSEMEKNA 350 QIVKTLKEDW 360 ESEKDLCLEN 370 LRKELSAKHQ 380 SEMEDLQNQF 390 QKELAEQRAE 400 LEKIFQDKNQ 410 AERALRNLES 420 HHQAAIEKLR 430 EDLQSEHGRC 440 LEDLEFKFKE 450 SEKEKQLELE 460 NLQASYEDLK 470 AQSQEEIRRL 480 WSQLDSARTS 490 RQELSELHEQ 500 LLARTSRVED 510 LEQLKQREKT 520 QHESELEQLR 530 IYFEKKLRDA 540 EKTYQEDLTL 550 LQQRLQGARE 560 DALLDSVEVG 570 LSCVGLEEKP 580 EKGRKDHVDE 590 LEPERHKESL 600 PRFQAELEES 610 HRHQLEALES 620 PLCIQHEGHV 630 SDRCCVETSA 640 LGHEWRLEPS 650 EGHSQELPWV 660 HLQGVQDGDL 670 EADTERAARV 680 LGLETEHKVQ 690 LSLLQTELKE 700 EIELLKIENR 710 NLYGKLQHET 720 RLKDDLEKVK 730 HNLIEDHQKE 740 LNNAKQKTEL 750 MKQEFQRKET 760 DWKVMKEELQ 770 REAEEKLTLM 780 LLELREKAES 790 EKQTIINKFE 800 LREAEMRQLQ 810 DQQAAQILDL 820 ERSLTEQQGR 830 LQQLEQDLTS 840 DDALHCSQCG 850 REPPTAQDGE 860 LAALHVKEDC 870 ALQLMLARSR 880 FLEERKEITE 890 KFSAEQDAFL 900 QEAQEQHARE 910 LQLLQERHQQ 920 QLLSVTAELE 930 ARHQAALGEL 940 TASLESKQGA 950 LLAARVAELQ 960 TKHAADLGAL 970 ETRHLSSLDS 980 LESCYLSEFQ 990 TIREEHRQAL 1000 ELLRADFEEQ 1010 LWKKDSLHQT 1020 ILTQELEKLK 1030 RKHEGELQSV 1040 RDHLRTEVST 1050 ELAGTVAHEL 1060 QGVHQGEFGS 1070 EKKTALHEKE 1080 ETLRLQSAQA 1090 QPFHQEEKES 1100 LSLQLQKKNH 1110 QVQQLKDQVL 1120 SLSHEIEECR 1130 SELEVLQQRR 1140 ERENREGANL 1150 LSMLKADVNL 1160 SHSERGALQD 1170 ALRRLLGLFG 1180 ETLRAAVTLR 1190 SRIGERVGLC 1200 LDDAGAGLAL 1210 STAPALEETW 1220 SDVALPELDR 1230 TLSECAEMSS 1240 VAEISSHMRE 1250 SFLMSPESVR 1260 ECEQPIRRVF 1270 QSLSLAVDGL 1280 MEMALDSSRQ 1290 LEEARQIHSR 1300 FEKEFSFKNE 1310 ETAQVVRKHQ 1320 ELLECLKEES 1330 AAKAELALEL 1340 HKTQGTLEGF 1350 KVETADLKEV 1360 LAGKEDSEHR 1370 LVLELESLRR 1380 QLQQAAQEQA 1390 ALREECTRLW 1400 SRGEATATDA 1410 EAREAALRKE 1420 VEDLTKEQSE 1430 TRKQAEKDRS 1440 ALLSQMKILE 1450 SELEEQLSQH 1460 RGCAKQAEAV 1470 TALEQQVASL 1480 DKHLRNQRQF 1490 MDEQAAEREH 1500 EREEFQQEIQ 1510 RLEGQLRQAA 1520 KPQPWGPRDS 1530 QQAPLDGEVE 1540 LLQQKLREKL 1550 DEFNELAIQK 1560 ESADRQVLMQ 1570 EEEIKRLEEM 1580 NINIRKKVAQ 1590 LQEEVEKQKN 1600 IVKGLEQDKE 1610 VLKKQQMSSL 1620 LLASTLQSTL 1630 DAGRCPEPPS 1640 GSPPEGPEIQ 1650 LEVTQRALLR 1660 RESEVLDLKE 1670 QLEKMKGDLE 1680 SKNEEILHLN 1690 LKLDMQNSQT 1700 AVSLRELEEE 1710 NTSLKVIYTR 1720 SSEIEELKAT 1730 IENLQENQKR 1740 LQKEKAEEIE 1750 QLHEVIEKLQ 1760 HELSLMGPVV 1770 HEVSDSQAGS 1780 LQSELLCSQA 1790 GGPRGQALQG 1800 ELEAALEAKE 1810 ALSRLLADQE 1820 RRHSQALEAL 1830 QQRLQGAEEA 1840 AELQLAELER 1850 NVALREAEVE 1860 DMASRIQEFE 1870 AALKAKEATI 1880 AERNLEIDAL 1890 NQRKAAHSAE 1900 LEAVLLALAR 1910 IRRALEQQPL 1920 AAGAAPPELQ 1930 WLRAQCARLS 1940 RQLQVLHQRF 1950 LRCQVELDRR 1960 QARRATAHTR 1970 VPGAHPQPRM 1980 DGGAKAQVTG 1990 DVEASHDAAL 2000 EPVVPDPQGD 2010 LQPVLVTLKD 2020 APLCKQEGVM 2030 SVLTVCQRQL 2040 QSELLLVKNE 2050 MRLSLEDGGK 2060 GKEKVLEDCQ 2070 LPKVDLVAQV 2080 KQLQEKLNRL 2090 LYSMTFQNVD 2100 AADTKSLWPM 2110 ASAHLLESSW 2120 SDDSCDGEEP 2130 DISPHIDTCD 2140 ANTATGGVTD 2150 VIKNQAIDAC 2160 DANTTPGGVT 2170 DVIKNWDSLI 2180 PDEMPDSPIQ 2190 EKSECQDMSL 2200 SSPTSVLGGS 2210 RHQSHTAEAG 2220 PRKSPVGMLD 2230 LSSWSSPEVL 2240 RKDWTLEPWP 2250 SLPVTPHSGA 2260 LSLCSADTSL 2270 GDRADTSLPQ 2280 TQGPGLLCSP 2290 GVSAAALALQ 2300 WAESPPADDH 2310 HVQRTAVEKD 2320 VEDFITTSFD 2330 SQETLSSPPP 2340 GLEGKADRSE 2350 KSDGSGFGAR 2360 LSPGSGGPEA 2370 QTAGPVTPAS 2380 ISGRFQPLPE 2390 AMKEKEVRPK 2400 HVKALLQMVR 2410 DESHQILALS 2420 EGLAPPSGEP 2430 HPPRKEDEIQ 2440 DISLHGGKTQ 2450 EVPTACPDWR 2460 GDLLQVVQEA 2470 FEKEQEMQGV 2480 ELQPRLSGSD 2490 LGGHSSLLER 2500 LEKIIREQGD 2510 LQEKSLEHLR 2520 LPDRSSLLSE 2530 IQALRAQLRM 2540 THLQNQEKLQ 2550 HLRTALTSAE 2560 ARGSQQEHQL 2570 RRQVELLAYK 2580 VEQEKCIAGD 2590 LQKTLSEEQE 2600 KANSVQKLLA 2610 AEQTVVRDLK 2620 SDLCESRQKS 2630 EQLSRSLCEV 2640 QQEVLQLRSM 2650 LSSKENELKA 2660 ALQELESEQG 2670 KGRALQSQLE 2680 EEQLRHLQRE 2690 SQSAKALEEL 2700 RASLETQRAQ 2710 SSRLCVALKH 2720 EQTAKDNLQK 2730 ELRIEHSRCE 2740 ALLAQERSQL 2750 SELQKDLAAE 2760 KSRTLELSEA 2770 LRHERLLTEQ 2780 LSQRTQEACV 2790 HQDTQAHHAL 2800 LQKLKEEKSR 2810 VVDLQAMLEK 2820 VQQQALHSQQ 2830 QLEAEAQKHC 2840 EALRREKEVS 2850 ATLKSTVEAL 2860 HTQKRELRCS 2870 LEREREKPAW 2880 LQAELEQSHP 2890 RLKEQEGRKA 2900 ARRSAEARQS 2910 PAAAEQWRKW 2920 QRDKEKLREL 2930 ELQRQRDLHK 2940 IKQLQQTVRD 2950 LESKDEVPGS 2960 RLHLGSARRA 2970 AGSDADHLRE 2980 QQRELEAMRQ 2990 RLLSAARLLT 3000 SFTSQAVDRT 3010 VNDWTSSNEK 3020 AVMSLLHTLE 3030 ELKSDLSRPT 3040 SSQKKMAAEL 3050 QFQFVDVLLK 3060 DNVSLTKALS 3070 TVTQEKLELS 3080 RAVSKLEKLL 3090 KHHLQKGCSP 3100 SRSERSAWKP 3110 DETAPQSSLR 3120 RPDPGRLPPA 3130 ASEEAHTSNV 3140 KMEKLYLHYL 3150 RAESFRKALI 3160 YQKKYLLLLI 3170 GGFQDSEQET 3180 LSMIAHLGVF 3190 PSKAERKITS 3200 RPFTRFRTAV 3210 RVVIAILRLR 3220 FLVKKWQEVD 3230 RKGALAQGKA 3240 PRPGPRARQP 3250 QSPPRTRESP 3260 PTRDVPSGHT 3270 RDPARGRRLA 3280 AAASPHSGGR 3290 ATPSPNSRLE 3300 RSLTASQDPE 3310 HSLTEYIHHL 3320 EVIQQRLGGV 3330 LPDSTSKKSC HPMIKQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0034451 centriolar satellite
Cellular Component GO:0005814 centriole
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005874 microtubule
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0060090 molecular adaptor activity
Biological Process GO:0060271 cilium assembly
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0007020 microtubule nucleation
Biological Process GO:0007052 mitotic spindle organization
Biological Process GO:0090316 positive regulation of intracellular protein transport
Biological Process GO:0007165 signal transduction

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.