Overview
| Uniprot ID | O95619 |
|---|
| Protein Name | YEATS domain-containing protein 4 |
|---|
| Gene Name | YEATS4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 212 |
RETINCLKNEIRKLE |
Function
Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:12963728, PubMed:14966270). Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac) (PubMed:29437725, PubMed:29900004, PubMed:30071723). Also able to recognize and bind crotonylated histone H3 (PubMed:30071723). May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo (PubMed:29463709). Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z (PubMed:29437725). H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell (By similarity)
Protein Sequence
10
MFKRMAEFGP
20
DSGGRVKGVT
30
IVKPIVYGNV
40
ARYFGKKREE
50
DGHTHQWTVY
60
VKPYRNEDMS
70
AYVKKIQFKL
80
HESYGNPLRV
90
VTKPPYEITE
100
TGWGEFEIII
110
KIFFIDPNER
120
PVTLYHLLKL
130
FQSDTNAMLG
140
KKTVVSEFYD
150
EMIFQDPTAM
160
MQQLLTTSRQ
170
LTLGAYKHET
180
EFAELEVKTR
190
EKLEAAKKKT
200
SFEIAELKER
210
LKASRETINC
220
LKNEIRKLEE
DDQAKDI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0035267 |
NuA4 histone acetyltransferase complex |
| Cellular Component |
GO:0016363 |
nuclear matrix |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0042393 |
histone binding |
| Molecular Function |
GO:0140044 |
histone H3K18ac reader activity |
| Molecular Function |
GO:0140119 |
histone H3K27ac reader activity |
| Molecular Function |
GO:0005200 |
structural constituent of cytoskeleton |
| Biological Process |
GO:0006338 |
chromatin remodeling |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0000278 |
mitotic cell cycle |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:1905168 |
positive regulation of double-strand break repair via homologous recombination |
| Biological Process |
GO:0042981 |
regulation of apoptotic process |
| Biological Process |
GO:0051726 |
regulation of cell cycle |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:2000779 |
regulation of double-strand break repair |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
Reference
PMID: N/A