Search Results
Overview
| Uniprot ID | O95677 |
|---|---|
| Protein Name | Protein phosphatase EYA4 |
| Gene Name | EYA4 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 52 | GDTPGSSKLEKSNLS |
| 55 | PGSSKLEKSNLSSTS |
Function
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity)
Protein Sequence
10
MEDSQDLNEQ
20
SVKKTCTESD
30
VSQSQNSRSM
40
EMQDLASPHT
50
LVGGGDTPGS
60
SKLEKSNLSS
70
TSVTTNGTGG
80
ENMTVLNTAD
90
WLLSCNTPSS
100
ATMSLLAVKT
110
EPLNSSETTA
120
TTGDGALDTF
130
TGSVITSSGY
140
SPRSAHQYSP
150
QLYPSKPYPH
160
ILSTPAAQTM
170
SAYAGQTQYS
180
GMQQPAVYTA
190
YSQTGQPYSL
200
PTYDLGVMLP
210
AIKTESGLSQ
220
TQSPLQSGCL
230
SYSPGFSTPQ
240
PGQTPYSYQM
250
PGSSFAPSST
260
IYANNSVSNS
270
TNFSGSQQDY
280
PSYTAFGQNQ
290
YAQYYSASTY
300
GAYMTSNNTA
310
DGTPSSTSTY
320
QLQESLPGLT
330
NQPGEFDTMQ
340
SPSTPIKDLD
350
ERTCRSSGSK
360
SRGRGRKNNP
370
SPPPDSDLER
380
VFVWDLDETI
390
IVFHSLLTGS
400
YAQKYGKDPP
410
MAVTLGLRME
420
EMIFNLADTH
430
LFFNDLEECD
440
QVHIDDVSSD
450
DNGQDLSTYS
460
FATDGFHAAA
470
SSANLCLPTG
480
VRGGVDWMRK
490
LAFRYRRVKE
500
LYNTYKNNVG
510
GLLGPAKRDA
520
WLQLRAEIEG
530
LTDSWLTNAL
540
KSLSIISTRS
550
NCINVLVTTT
560
QLIPALAKVL
570
LYSLGGAFPI
580
ENIYSATKIG
590
KESCFERIMQ
600
RFGRKVVYVV
610
IGDGVEEEQA
620
AKKHNMPFWR
630
ISSHSDLLAL
HQALELEYL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004725 | protein tyrosine phosphatase activity |
| Biological Process | GO:0009653 | anatomical structure morphogenesis |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| Biological Process | GO:0045739 | positive regulation of DNA repair |
| Biological Process | GO:0007601 | visual perception |
Reference
PMID: N/A