Search Results
Overview
| Uniprot ID | O95684 |
|---|---|
| Protein Name | Centrosomal protein 43 |
| Gene Name | CEP43 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 214 | SLSEPKSKSSLHLLS |
| 275 | GLRKEPRKQAGSLAS |
| 315 | KRGNTVLKDLKLISD |
Function
Required for anchoring microtubules to the centrosomes (PubMed:16314388, PubMed:28659385). Required for ciliation (PubMed:28625565, PubMed:28659385)
Protein Sequence
10
MAATAAAVVA
20
EEDTELRDLL
30
VQTLENSGVL
40
NRIKAELRAA
50
VFLALEEQEK
60
VENKTPLVNE
70
SLKKFLNTKD
80
GRLVASLVAE
90
FLQFFNLDFT
100
LAVFQPETST
110
LQGLEGRENL
120
ARDLGIIEAE
130
GTVGGPLLLE
140
VIRRCQQKEK
150
GPTTGEGALD
160
LSDVHSPPKS
170
PEGKTSAQTT
180
PSKIPRYKGQ
190
GKKKTSGQKA
200
GDKKANDEAN
210
QSDTSVSLSE
220
PKSKSSLHLL
230
SHETKIGSFL
240
SNRTLDGKDK
250
AGLCPDEDDM
260
EGDSFFDDPI
270
PKPEKTYGLR
280
KEPRKQAGSL
290
ASLSDAPPLK
300
SGLSSLAGAP
310
SLKDSESKRG
320
NTVLKDLKLI
330
SDKIGSLGLG
340
TGEDDDYVDD
350
FNSTSHRSEK
360
SEISIGEEIE
370
EDLSVEIDDI
380
NTSDKLDDLT
390
QDLTVSQLSD
VADYLEDVA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005814 | centriole |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0036064 | ciliary basal body |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0030292 | protein tyrosine kinase inhibitor activity |
| Biological Process | GO:0030030 | cell projection organization |
| Biological Process | GO:0034453 | microtubule anchoring |
| Biological Process | GO:0006469 | negative regulation of protein kinase activity |
| Biological Process | GO:0030307 | positive regulation of cell growth |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.