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Overview

Uniprot IDO95721
Protein NameSynaptosomal-associated protein 29
Gene NameSNAP29
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
154 KEAISTSKEQEAKYQ
169 ASHPNLRKLDDTDPV
191 MSTDAYPKNPHLRAY
201 HLRAYHQKIDSNLDE

Function

SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions

Protein Sequence

10 MSAYPKSYNP 20 FDDDGEDEGA 30 RPAPWRDARD 40 LPDGPDAPAD 50 RQQYLRQEVL 60 RRAEATAAST 70 SRSLALMYES 80 EKVGVASSEE 90 LARQRGVLER 100 TEKMVDKMDQ 110 DLKISQKHIN 120 SIKSVFGGLV 130 NYFKSKPVET 140 PPEQNGTLTS 150 QPNNRLKEAI 160 STSKEQEAKY 170 QASHPNLRKL 180 DDTDPVPRGA 190 GSAMSTDAYP 200 KNPHLRAYHQ 210 KIDSNLDELS 220 MGLGRLKDIA 230 LGMQTEIEEQ 240 DDILDRLTTK 250 VDKLDVNIKS TERKVRQL

Gene Ontology

Classification GO ID Description
Biological Process GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane
Cellular Component GO:0005776 autophagosome
Cellular Component GO:0000421 autophagosome membrane
Cellular Component GO:0035577 azurophil granule membrane
Cellular Component GO:0020018 ciliary pocket membrane
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098793 presynapse
Cellular Component GO:0031201 SNARE complex
Molecular Function GO:0005484 SNAP receptor activity
Molecular Function GO:0019905 syntaxin binding
Biological Process GO:0097352 autophagosome maturation
Biological Process GO:0016240 autophagosome membrane docking
Biological Process GO:0009267 cellular response to starvation
Biological Process GO:0060271 cilium assembly
Biological Process GO:0006887 exocytosis
Biological Process GO:0016236 macroautophagy
Biological Process GO:0061025 membrane fusion
Biological Process GO:0015031 protein transport
Biological Process GO:0016082 synaptic vesicle priming
Biological Process GO:0006906 vesicle fusion
Biological Process GO:0006903 vesicle targeting

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.