Search Results
Overview
| Uniprot ID | O95749 |
|---|---|
| Protein Name | Geranylgeranyl pyrophosphate synthase |
| Gene Name | GGPS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 25 | YLLQLPGKQVRTKLS |
Function
Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins
Protein Sequence
10
MEKTQETVQR
20
ILLEPYKYLL
30
QLPGKQVRTK
40
LSQAFNHWLK
50
VPEDKLQIII
60
EVTEMLHNAS
70
LLIDDIEDNS
80
KLRRGFPVAH
90
SIYGIPSVIN
100
SANYVYFLGL
110
EKVLTLDHPD
120
AVKLFTRQLL
130
ELHQGQGLDI
140
YWRDNYTCPT
150
EEEYKAMVLQ
160
KTGGLFGLAV
170
GLMQLFSDYK
180
EDLKPLLNTL
190
GLFFQIRDDY
200
ANLHSKEYSE
210
NKSFCEDLTE
220
GKFSFPTIHA
230
IWSRPESTQV
240
QNILRQRTEN
250
IDIKKYCVHY
260
LEDVGSFEYT
270
RNTLKELEAK
280
AYKQIDARGG
290
NPELVALVKH
300
LSKMFKEENE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0004337 | (2E,6E)-farnesyl diphosphate synthase activity |
| Molecular Function | GO:0004161 | dimethylallyltranstransferase activity |
| Molecular Function | GO:0004311 | geranylgeranyl diphosphate synthase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0045337 | farnesyl diphosphate biosynthetic process |
| Biological Process | GO:0033384 | geranyl diphosphate biosynthetic process |
| Biological Process | GO:0033386 | geranylgeranyl diphosphate biosynthetic process |
| Biological Process | GO:0008299 | isoprenoid biosynthetic process |
| Biological Process | GO:0006720 | isoprenoid metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.