Search Results

Overview

Uniprot IDO95757
Protein NameHeat shock 70 kDa protein 4L
Gene NameHSPA4L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
249 DYFCDEFKTKYKINV
388 AILSPAFKVREFSIT
573 DRLNQTLKKGKVKSI
574 RLNQTLKKGKVKSID
757 SKMNAQNKLSLTQDP
831 KDSSQHTKSSGEMEV

Function

Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase

Protein Sequence

10 MSVVGIDLGF 20 LNCYIAVARS 30 GGIETIANEY 40 SDRCTPACIS 50 LGSRTRAIGN 60 AAKSQIVTNV 70 RNTIHGFKKL 80 HGRSFDDPIV 90 QTERIRLPYE 100 LQKMPNGSAG 110 VKVRYLEEER 120 PFAIEQVTGM 130 LLAKLKETSE 140 NALKKPVADC 150 VISIPSFFTD 160 AERRSVMAAA 170 QVAGLNCLRL 180 MNETTAVALA 190 YGIYKQDLPP 200 LDEKPRNVVF 210 IDMGHSAYQV 220 LVCAFNKGKL 230 KVLATTFDPY 240 LGGRNFDEAL 250 VDYFCDEFKT 260 KYKINVKENS 270 RALLRLYQEC 280 EKLKKLMSAN 290 ASDLPLNIEC 300 FMNDLDVSSK 310 MNRAQFEQLC 320 ASLLARVEPP 330 LKAVMEQANL 340 QREDISSIEI 350 VGGATRIPAV 360 KEQITKFFLK 370 DISTTLNADE 380 AVARGCALQC 390 AILSPAFKVR 400 EFSITDLVPY 410 SITLRWKTSF 420 EDGSGECEVF 430 CKNHPAPFSK 440 VITFHKKEPF 450 ELEAFYTNLH 460 EVPYPDARIG 470 SFTIQNVFPQ 480 SDGDSSKVKV 490 KVRVNIHGIF 500 SVASASVIEK 510 QNLEGDHSDA 520 PMETETSFKN 530 ENKDNMDKMQ 540 VDQEEGHQKC 550 HAEHTPEEEI 560 DHTGAKTKSA 570 VSDKQDRLNQ 580 TLKKGKVKSI 590 DLPIQSSLCR 600 QLGQDLLNSY 610 IENEGKMIMQ 620 DKLEKERNDA 630 KNAVEEYVYD 640 FRDRLGTVYE 650 KFITPEDLSK 660 LSAVLEDTEN 670 WLYEDGEDQP 680 KQVYVDKLQE 690 LKKYGQPIQM 700 KYMEHEERPK 710 ALNDLGKKIQ 720 LVMKVIEAYR 730 NKDERYDHLD 740 PTEMEKVEKC 750 ISDAMSWLNS 760 KMNAQNKLSL 770 TQDPVVKVSE 780 IVAKSKELDN 790 FCNPIIYKPK 800 PKAEVPEDKP 810 KANSEHNGPM 820 DGQSGTETKS 830 DSTKDSSQHT KSSGEMEVD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000774 adenyl-nucleotide exchange factor activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Biological Process GO:0006457 protein folding
Biological Process GO:0006986 response to unfolded protein

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.