Search Results

Overview

Uniprot IDO95758
Protein NamePolypyrimidine tract-binding protein 3
Gene NamePTBP3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
137 YSNHRELKTDNLPNQ
257 TLRIDFSKLTSLNVK
264 KLTSLNVKYNNDKSR
449 QEDQGLTKDFSNSPL

Function

RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U)

Protein Sequence

10 MDGVVTDLIT 20 VGLKRGSDEL 30 LSSGIINGPF 40 TMNSSTPSTA 50 NGNDSKKFKR 60 DRPPCSPSRV 70 LHLRKIPCDV 80 TEAEIISLGL 90 PFGKVTNLLM 100 LKGKSQAFLE 110 MASEEAAVTM 120 VNYYTPITPH 130 LRSQPVYIQY 140 SNHRELKTDN 150 LPNQARAQAA 160 LQAVSAVQSG 170 SLALSGGPSN 180 EGTVLPGQSP 190 VLRIIIENLF 200 YPVTLEVLHQ 210 IFSKFGTVLK 220 IITFTKNNQF 230 QALLQYADPV 240 NAHYAKMALD 250 GQNIYNACCT 260 LRIDFSKLTS 270 LNVKYNNDKS 280 RDFTRLDLPT 290 GDGQPSLEPP 300 MAAAFGAPGI 310 ISSPYAGAAG 320 FAPAIGFPQA 330 TGLSVPAVPG 340 ALGPLTITSS 350 AVTGRMAIPG 360 ASGIPGNSVL 370 LVTNLNPDLI 380 TPHGLFILFG 390 VYGDVHRVKI 400 MFNKKENALV 410 QMADANQAQL 420 AMNHLSGQRL 430 YGKVLRATLS 440 KHQAVQLPRE 450 GQEDQGLTKD 460 FSNSPLHRFK 470 KPGSKNFQNI 480 FPPSATLHLS 490 NIPPSVTVDD 500 LKNLFIEAGC 510 SVKAFKFFQK 520 DRKMALIQLG 530 SVEEAIQALI 540 ELHNHDLGEN 550 HHLRVSFSKS TI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0009653 anatomical structure morphogenesis
Biological Process GO:0043249 erythrocyte maturation
Biological Process GO:0006397 mRNA processing
Biological Process GO:0033119 negative regulation of RNA splicing
Biological Process GO:0045595 regulation of cell differentiation
Biological Process GO:0043484 regulation of RNA splicing
Biological Process GO:0008380 RNA splicing

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.