Search Results

Overview

Uniprot IDO95785
Protein NameProtein Wiz
Gene NameWIZ
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1108 NPPGPSPKALAKMMG
1112 PSPKALAKMMGGAGP
1138 LHISPLAKKLPPPPG
1139 HISPLAKKLPPPPGS
1175 AAPSLPKKLKPEQIR
1322 PLAGRPGKPGAGPAQ
1356 YLGSVAAKRPLQEDR
1382 IQTELPFKAKTLHEK
1384 TELPFKAKTLHEKTS
1448 WIKHRPQKVGAYRSY
1464 QGGRPFTKKFRSAGH
1477 GHGRDSDKRPSLGLA
1534 HQRQNINKFERRQAR
933 GLPPGLAKKSSSLKE
934 LPPGLAKKSSSLKEV
955 PGLLSLAKPLDAPAV
964 LDAPAVNKAIKSPPG
967 PAVNKAIKSPPGFSA
988 PSSPLLKKTPLALAG

Function

May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity)

Protein Sequence

10 MEGSLAGSLA 20 APDRPQGPER 30 LPGPAPRENI 40 EGGAEAAEGE 50 GGIFRSTRYL 60 PVTKEGPRDI 70 LDGRGGISGT 80 PDGRGPWEHP 90 LVQEAGEGIL 100 SERRFEDSVI 110 VRTMKPHAEL 120 EGSRRFLHHR 130 GEPRLLEKHA 140 QGRPRFDWLQ 150 DEDEQGSPQD 160 AGLHLDLPAQ 170 PPPLAPFRRV 180 FVPVEDTPKT 190 LDMAVVGGRE 200 DLEDLEGLAQ 210 PSEWGLPTSA 220 SEVATQTWTV 230 NSEASVERLQ 240 PLLPPIRTGP 250 YLCELLEEVA 260 EGVASPDEDE 270 DEEPAVFPCI 280 ECSIYFKQKE 290 HLLEHMSQHR 300 RAPGQEPPAD 310 LAPLACGECG 320 WAFADPTALE 330 QHRQLHQASR 340 EKIIEEIQKL 350 KQVPGDEGRE 360 ARLQCPKCVF 370 GTNSSRAYVQ 380 HAKLHMREPP 390 GQTTKEPFGG 400 SSGAGSPSPE 410 ASALLYQPYG 420 AAVGLSACVF 430 CGFPAPSESL 440 LREHVRLVHA 450 HPHWEEDGEA 460 YEEDPASQPG 470 TSQDAHACFP 480 DTAVDYFGKA 490 EPSLAPMWRE 500 NPAGYDPSLA 510 FGPGCQQLSI 520 RDFPLSKPLL 530 HGTGQRPLGR 540 LAFPSTLAST 550 PYSLQLGRNK 560 STVHPQGLGE 570 RRRPWSEEEE 580 EEEEEEDVVL 590 TSEMDFSPEN 600 GVFSPLATPS 610 LIPQAALELK 620 QAFREALQAV 630 EATQGQQQQL 640 RGMVPIVLVA 650 KLGPQVMAAA 660 RVPPRLQPEE 670 LGLAGAHPLD 680 FLLLDAPLGG 690 PLGLDTLLDG 700 DPAMALKHEE 710 RKCPYCPDRF 720 HNGIGLANHV 730 RGHLNRVGVS 740 YNVRHFISAE 750 EVKAIERRFS 760 FQKKKKKVAN 770 FDPGTFSLMR 780 CDFCGAGFDT 790 RAGLSSHARA 800 HLRDFGITNW 810 ELTVSPINIL 820 QELLATSAAE 830 QPPSPLGREP 840 GGPPGSFLTS 850 RRPRLPLTVP 860 FPPTWAEDPG 870 PAYGDAQSLT 880 TCEVCGACFE 890 TRKGLSSHAR 900 SHLRQLGVAE 910 SESSGAPIDL 920 LYELVKQKGL 930 PDAHLGLPPG 940 LAKKSSSLKE 950 VVAGAPRPGL 960 LSLAKPLDAP 970 AVNKAIKSPP 980 GFSAKGLGHP 990 PSSPLLKKTP 1000 LALAGSPTPK 1010 NPEDKSPQLS 1020 LSPRPASPKA 1030 QWPQSEDEGP 1040 LNLTSGPEPA 1050 RDIRCEFCGE 1060 FFENRKGLSS 1070 HARSHLRQMG 1080 VTEWYVNGSP 1090 IDTLREILKR 1100 RTQSRPGGPP 1110 NPPGPSPKAL 1120 AKMMGGAGPG 1130 SSLEARSPSD 1140 LHISPLAKKL 1150 PPPPGSPLGH 1160 SPTASPPPTA 1170 RKMFPGLAAP 1180 SLPKKLKPEQ 1190 IRVEIKREML 1200 PGALHGELHP 1210 SEGPWGAPRE 1220 DMTPLNLSSR 1230 AEPVRDIRCE 1240 FCGEFFENRK 1250 GLSSHARSHL 1260 RQMGVTEWSV 1270 NGSPIDTLRE 1280 ILKKKSKPCL 1290 IKKEPPAGDL 1300 APALAEDGPP 1310 TVAPGPVQSP 1320 LPLSPLAGRP 1330 GKPGAGPAQV 1340 PRELSLTPIT 1350 GAKPSATGYL 1360 GSVAAKRPLQ 1370 EDRLLPAEVK 1380 AKTYIQTELP 1390 FKAKTLHEKT 1400 SHSSTEACCE 1410 LCGLYFENRK 1420 ALASHARAHL 1430 RQFGVTEWCV 1440 NGSPIETLSE 1450 WIKHRPQKVG 1460 AYRSYIQGGR 1470 PFTKKFRSAG 1480 HGRDSDKRPS 1490 LGLAPGGLAV 1500 VGRSAGGEPG 1510 PEAGRAADGG 1520 ERPLAASPPG 1530 TVKAEEHQRQ 1540 NINKFERRQA 1550 RPPDASAARG 1560 GEDTNDLQQK 1570 LEEVRQPPPR 1580 VRPVPSLVPR 1590 PPQTSLVKFV 1600 GNIYTLKCRF 1610 CEVEFQGPLS 1620 IQEEWVRHLQ 1630 RHILEMNFSK 1640 ADPPPEESQA 1650 PQAQTAAAEA P

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function GO:1990226 histone methyltransferase binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function GO:0001222 transcription corepressor binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0010571 positive regulation of nuclear cell cycle DNA replication
Biological Process GO:0050821 protein stabilization
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.