Search Results

Overview

Uniprot IDO95793
Protein NameDouble-stranded RNA-binding protein Staufen homolog 1
Gene NameSTAU1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
149 GKTRQAAKHDAAAKA
155 AKHDAAAKALRILQN
299 AQIQQAKKEKEPEYT
367 QPTKPALKSEEKTPI

Function

Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site

Protein Sequence

10 MSQVQVQVQN 20 PSAALSGSQI 30 LNKNQSLLSQ 40 PLMSIPSTTS 50 SLPSENAGRP 60 IQNSALPSAS 70 ITSTSAAAES 80 ITPTVELNAL 90 CMKLGKKPMY 100 KPVDPYSRMQ 110 STYNYNMRGG 120 AYPPRYFYPF 130 PVPPLLYQVE 140 LSVGGQQFNG 150 KGKTRQAAKH 160 DAAAKALRIL 170 QNEPLPERLE 180 VNGRESEEEN 190 LNKSEISQVF 200 EIALKRNLPV 210 NFEVARESGP 220 PHMKNFVTKV 230 SVGEFVGEGE 240 GKSKKISKKN 250 AAIAVLEELK 260 KLPPLPAVER 270 VKPRIKKKTK 280 PIVKPQTSPE 290 YGQGINPISR 300 LAQIQQAKKE 310 KEPEYTLLTE 320 RGLPRRREFV 330 MQVKVGNHTA 340 EGTGTNKKVA 350 KRNAAENMLE 360 ILGFKVPQAQ 370 PTKPALKSEE 380 KTPIKKPGDG 390 RKVTFFEPGS 400 GDENGTSNKE 410 DEFRMPYLSH 420 QQLPAGILPM 430 VPEVAQAVGV 440 SQGHHTKDFT 450 RAAPNPAKAT 460 VTAMIARELL 470 YGGTSPTAET 480 ILKNNISSGH 490 VPHGPLTRPS 500 EQLDYLSRVQ 510 GFQVEYKDFP 520 KNNKNEFVSL 530 INCSSQPPLI 540 SHGIGKDVES 550 CHDMAALNIL 560 KLLSELDQQS 570 TEMPRTGNGP MSVCGRC

Gene Ontology

Classification GO ID Description
Biological Process GO:0007281 germ cell development
Cellular Component GO:0044297 cell body
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0036464 cytoplasmic ribonucleoprotein granule
Cellular Component GO:0010494 cytoplasmic stress granule
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0032839 dendrite cytoplasm
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0016020 membrane
Cellular Component GO:0005875 microtubule associated complex
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0005791 rough endoplasmic reticulum
Molecular Function GO:0003725 double-stranded RNA binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0008157 protein phosphatase 1 binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0098964 anterograde dendritic transport of messenger ribonucleoprotein complex
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0008298 intracellular mRNA localization
Biological Process GO:0000512 lncRNA-mediated post-transcriptional gene silencing
Biological Process GO:0099010 modification of postsynaptic structure
Biological Process GO:0046726 positive regulation by virus of viral protein levels in host cell
Biological Process GO:1900273 positive regulation of long-term synaptic potentiation
Biological Process GO:0045070 positive regulation of viral genome replication
Biological Process GO:0035418 protein localization to synapse

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.