Search Results

Overview

Uniprot ID	O95810
Protein Name	Caveolae-associated protein 2
Gene Name	CAVIN2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
102	NDLTKLSKYQASTSN
286	HQKISSGKSSPFKVS
99	GIQNDLTKLSKYQAS

Function

Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity)

Protein Sequence

10 MGEDAAQAEK 20 FQHPGSDMRQ 30 EKPSSPSPMP 40 SSTPSPSLNL 50 GNTEEAIRDN 60 SQVNAVTVLT 70 LLDKLVNMLD 80 AVQENQHKME 90 QRQISLEGSV 100 KGIQNDLTKL 110 SKYQASTSNT 120 VSKLLEKSRK 130 VSAHTRAVKE 140 RMDRQCAQVK 150 RLENNHAQLL 160 RRNHFKVLIF 170 QEENEIPASV 180 FVKQPVSGAV 190 EGKEELPDEN 200 KSLEETLHTV 210 DLSSDDDLPH 220 DEEALEDSAE 230 EKVEESRAEK 240 IKRSSLKKVD 250 SLKKAFSRQN 260 IEKKMNKLGT 270 KIVSVERREK 280 IKKSLTSNHQ 290 KISSGKSSPF 300 KVSPLTFGRK 310 KVREGESHAE 320 NETKSEDLPS 330 SEQMPNDQEE 340 ESFAEGHSEA 350 SLASALVEGE 360 IAEEAAEKAT 370 SRGSNSGMDS 380 NIDLTIVEDE 390 EEESVALEQA 400 QKVRYEGSYA 410 LTSEEAERSD 420 GDPVQPAVLQ VHQTS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005901	caveola
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0045121	membrane raft
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0001786	phosphatidylserine binding
Molecular Function	GO:0005543	phospholipid binding
Molecular Function	GO:0005080	protein kinase C binding
Biological Process	GO:0097320	plasma membrane tubulation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.